产品
编 号:F595009
分子式:C19H15N5S2
分子量:377.49
产品类型
结构图
CAS No: 1601496-05-2
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产品详情
生物活性:
GSK-843 (GSK'843) is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds RIP3 kinase domain with an IC50 of 8.6 nM, and inhibits kinase activity with an IC50 of 6.5 nM. GSK-843 can be used for the research of inflammation.
体外研究:
GSK-843 (3-10 μM; 18 h) induces apoptosis.?GSK-843 (0.3-3 μM; 18 h) suppresses TNF-induced death and virus-induced cell necrosis.