产品
编 号：F594613
分子式：C22H28ClN3O2
分子量：401.93
分子式：C22H28ClN3O2
分子量：401.93
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
询价
询价
100mg
询价
询价
结构图
CAS No: 55750-05-5
产品详情
生物活性：
Caroverine (Tinnex) hydrochloride is a potent, competitive and reversible antagonist of NMDA and AMPA glutamate receptor. Caroverine hydrochloride is also an antioxidant and calcium-blocking agent that exhibits vasorelaxant action. Caroverine hydrochloride can be used for the research of inner ear tinnitus.
体内研究：
Caroverine (1.44 mg/rat; s.c; 1.0 mL/h for 72 h) attenuates impulse noise-induced hearing loss in the rat.Animal Model:Sprague-Dawley rats of either sex (250-300 g) received impulse noise exposure
Dosage:1.44 mg/rat
Administration:20 mg/mL; s.c. 1.0 mL/h for 72 h
Result:Significantly protected the cochlea against impulse noise trauma.
体外研究：
Caroverine (1 μM; pretreated for 10 min) inhibits the pressor response to KCl (80 mM) andnoradrenaline (1 μM) in the rat hindquarter preparation. Caroverine markedly suppresses the contraction caused by KCl (40 mM) in the rat isolated aorta.
Caroverine (Tinnex) hydrochloride is a potent, competitive and reversible antagonist of NMDA and AMPA glutamate receptor. Caroverine hydrochloride is also an antioxidant and calcium-blocking agent that exhibits vasorelaxant action. Caroverine hydrochloride can be used for the research of inner ear tinnitus.
体内研究：
Caroverine (1.44 mg/rat; s.c; 1.0 mL/h for 72 h) attenuates impulse noise-induced hearing loss in the rat.Animal Model:Sprague-Dawley rats of either sex (250-300 g) received impulse noise exposure
Dosage:1.44 mg/rat
Administration:20 mg/mL; s.c. 1.0 mL/h for 72 h
Result:Significantly protected the cochlea against impulse noise trauma.
体外研究：
Caroverine (1 μM; pretreated for 10 min) inhibits the pressor response to KCl (80 mM) andnoradrenaline (1 μM) in the rat hindquarter preparation. Caroverine markedly suppresses the contraction caused by KCl (40 mM) in the rat isolated aorta.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备