产品
编 号：F594342
分子式：C8H18N3O8P
分子量：315.22
分子式：C8H18N3O8P
分子量：315.22
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CAS No: 149394-66-1
产品详情
生物活性：
Cidofovir (GS 0504; HPMPC; (S)-HPMPC) dihydrate is an acyclic monophosphate nucleotide analogue and CMV inhibitor with antiviral activity. Cidofovir dihydrate inhibits cytomegalovirus (CMV) replication by selectively inhibiting viral DNA polymerase. Cidofovir dihydrate induces apoptosis and can be used in studies of AIDS cytomegalovirus retinitis, herpes, and cancer. Cidofovir dihydrate also has anti-orthopoxvirus and anti-variola activities.
体内研究：
Cidofovir (subcutaneous injection, 100 mg/kg, 3-6 days interval, 21 days)dihydrate is highly protective against death from cowpox virus (CPV) infection at high doses in female weanling BALB/c mice.Animal Model:Female weanling BALB/c mice infected with cowpox virus (CPV)
Dosage:100 mg/kg
Administration:Subcutaneous injection; 3-6 days interval; 21 days
Result:Prevented 80-100% of mouse deaths when administered on the first 4-3 days before infection.Protected 35-50% of mice when administered on the fourth day after infection, and 10-20% when administered on the sixth day.
体外研究：
Cidofovir (5-100 μM, 72 hours) dihydrate has antiviral activity against feline herpesvirus type-1 (FHV-1) with an IC50 of 11 μM, and can reduce Crandell-Reese feline kidney cells counts in a dose dependent manner.Cidofovir (10-1000 μM, 24-120 hours) dihydrate can reduce cancer cell viability and induces apoptosis.
Cidofovir (GS 0504; HPMPC; (S)-HPMPC) dihydrate is an acyclic monophosphate nucleotide analogue and CMV inhibitor with antiviral activity. Cidofovir dihydrate inhibits cytomegalovirus (CMV) replication by selectively inhibiting viral DNA polymerase. Cidofovir dihydrate induces apoptosis and can be used in studies of AIDS cytomegalovirus retinitis, herpes, and cancer. Cidofovir dihydrate also has anti-orthopoxvirus and anti-variola activities.
体内研究：
Cidofovir (subcutaneous injection, 100 mg/kg, 3-6 days interval, 21 days)dihydrate is highly protective against death from cowpox virus (CPV) infection at high doses in female weanling BALB/c mice.Animal Model:Female weanling BALB/c mice infected with cowpox virus (CPV)
Dosage:100 mg/kg
Administration:Subcutaneous injection; 3-6 days interval; 21 days
Result:Prevented 80-100% of mouse deaths when administered on the first 4-3 days before infection.Protected 35-50% of mice when administered on the fourth day after infection, and 10-20% when administered on the sixth day.
体外研究：
Cidofovir (5-100 μM, 72 hours) dihydrate has antiviral activity against feline herpesvirus type-1 (FHV-1) with an IC50 of 11 μM, and can reduce Crandell-Reese feline kidney cells counts in a dose dependent manner.Cidofovir (10-1000 μM, 24-120 hours) dihydrate can reduce cancer cell viability and induces apoptosis.
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