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编 号：F588441
分子式：C4H11Cl2N2O2P
分子量：221.02
分子式：C4H11Cl2N2O2P
分子量：221.02
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CAS No: 10159-53-2
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生物活性：
Phosphoramide mustard is a biologically active metabolite of Cyclophosphamide (HY-17420), with anticancer activitiy. Phosphoramide mustard induces DNA damage.
体内研究：
Phosphoramide mustard (2.1-20.7 mg/kg; i.p.; daily; for 5 days) inhibits subcutaneous tumor growth in rats.Phosphoramide mustard exhibits terminal elimination half-lives (rat 15.1 min) following intravenous administration (rat 59.4 mg/kg).Animal Model:Rat, subcutaneously implanted Walker 256 carcinosarcoma tumor
Dosage:2.1 mg/kg, 4.8 mg/kg, 10.4 mg/kg, 20.7 mg/kg
Administration:Intraperitoneal injection, once daily, for 5 consecutive days
Result:Required to produce 50% inhibition of subcutaneous tumor growth with dose of 12 mg/kg.
Animal Model:Rats
Dosage:59.4 mg/kg (Pharmacokinetic Analysis)
Administration:Intravenous injection
Result:T1/2 (15.1 min).
体外研究：
Phosphoramide mustard causes cytotoxicity through forming cross-linked DNA adducts which inhibit DNA strand separation during replication.Phosphoramide mustard (3-6 μM; 48 hours) reduces cell viability in rat spontaneously immortalized granulosa cells (SIGCs).Phosphoramide mustard (3-6 μM; 24-48 hours) induces DNA adduct formation and ovarian DNA damage.Phosphoramide mustard (3-6 μM; 24-48 hours) increases DNA damage responses (DDR) gene mRNA expression levels and DDR proteins.
Phosphoramide mustard is a biologically active metabolite of Cyclophosphamide (HY-17420), with anticancer activitiy. Phosphoramide mustard induces DNA damage.
体内研究：
Phosphoramide mustard (2.1-20.7 mg/kg; i.p.; daily; for 5 days) inhibits subcutaneous tumor growth in rats.Phosphoramide mustard exhibits terminal elimination half-lives (rat 15.1 min) following intravenous administration (rat 59.4 mg/kg).Animal Model:Rat, subcutaneously implanted Walker 256 carcinosarcoma tumor
Dosage:2.1 mg/kg, 4.8 mg/kg, 10.4 mg/kg, 20.7 mg/kg
Administration:Intraperitoneal injection, once daily, for 5 consecutive days
Result:Required to produce 50% inhibition of subcutaneous tumor growth with dose of 12 mg/kg.
Animal Model:Rats
Dosage:59.4 mg/kg (Pharmacokinetic Analysis)
Administration:Intravenous injection
Result:T1/2 (15.1 min).
体外研究：
Phosphoramide mustard causes cytotoxicity through forming cross-linked DNA adducts which inhibit DNA strand separation during replication.Phosphoramide mustard (3-6 μM; 48 hours) reduces cell viability in rat spontaneously immortalized granulosa cells (SIGCs).Phosphoramide mustard (3-6 μM; 24-48 hours) induces DNA adduct formation and ovarian DNA damage.Phosphoramide mustard (3-6 μM; 24-48 hours) increases DNA damage responses (DDR) gene mRNA expression levels and DDR proteins.
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