产品
编 号：F582547
分子式：C73H97N11O22
分子量：1480.61
分子式：C73H97N11O22
分子量：1480.61
产品类型
规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
询价
询价
100mg
询价
询价
结构图
CAS No: 1279680-68-0
产品详情
生物活性：
CL2A-SN-38 is a agent-linker conjugate composed of a potent a DNA Topoisomerase I inhibitor SN-38 and a linker CL2A to make antibody agent conjugate (ADC). CL2A-SN-38 provides significant and specific antitumor effects against a range of human solid tumor types. CL2A-SN-38 uses hydrolyzable linker to deliver active agents within tumor cells and in the tumor microenvironment, resulting in bystander effects.
体内研究：
CL2A-SN-38 偶联抗 Trop-2 人源化抗体 hRS7 (腹腔注射，0.2或0.4mg/kg，每周2次，4周) 均能显著抑制人结肠 (COLO 205) 或胰腺小鼠肿瘤异种移植物模型的肿瘤生长 (Capan-1)。
CL2A-SN-38 is a agent-linker conjugate composed of a potent a DNA Topoisomerase I inhibitor SN-38 and a linker CL2A to make antibody agent conjugate (ADC). CL2A-SN-38 provides significant and specific antitumor effects against a range of human solid tumor types. CL2A-SN-38 uses hydrolyzable linker to deliver active agents within tumor cells and in the tumor microenvironment, resulting in bystander effects.
体内研究：
CL2A-SN-38 偶联抗 Trop-2 人源化抗体 hRS7 (腹腔注射，0.2或0.4mg/kg，每周2次，4周) 均能显著抑制人结肠 (COLO 205) 或胰腺小鼠肿瘤异种移植物模型的肿瘤生长 (Capan-1)。
产品资料
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