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编 号：F575476
分子式：C24H35NO4
分子量：401.54
分子式：C24H35NO4
分子量：401.54
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CAS No: 7085-45-2
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生物活性：
Biperiden (KL 373) lactate is an orally active non-selective muscarinic receptor antagonist that competitively binds to M1 muscarinic receptors. Biperiden (KL 373) lactate inhibits acetylcholine and enhances dopamine signaling in the central nervous system. Biperiden (KL 373) lactate has the potential for the research of Parkinson's disease and other related psychiatric disorders.
体内研究：
Biperiden lactate (intraperitoneal injection, 10 mg/kg, everyday, 3 weeks) reduces tumor size by 83% in subcutaneous xenograft mouse using Panc-1 human pancreatic ductal adenocarcinoma cells. Biperiden lactate (intraperitoneal injection, 8 mg/kg, every 8 hours, 10 days) can reduce frequency of spontaneous seizures and extracellular hippocampal glutamate levels while cause a long-term decrease in hippocampal excitability.Animal Model:Subcutaneous xenograft mouse using Panc-1 human pancreatic ductal adenocarcinoma cells
Dosage:10 mg/kg
Administration:Intraperitoneal injection; everyday; 3 weeks
Result:Tumor size reduced by 83%.
Animal Model:Male Wistar rats (200-250 g)
Dosage:8 mg/kg
Administration:Intraperitoneal injection; every 8 hours; 10 days
Result:Reduced late seizures by about three times with no affecting emotional memory damage
体外研究：
Biperiden lactate (29.6 μg/ml, 72 hours) can significantly induce apoptosis and inhibit proliferation at high doses in human pancreatic ductal adenocarcinoma cells.
Biperiden (KL 373) lactate is an orally active non-selective muscarinic receptor antagonist that competitively binds to M1 muscarinic receptors. Biperiden (KL 373) lactate inhibits acetylcholine and enhances dopamine signaling in the central nervous system. Biperiden (KL 373) lactate has the potential for the research of Parkinson's disease and other related psychiatric disorders.
体内研究：
Biperiden lactate (intraperitoneal injection, 10 mg/kg, everyday, 3 weeks) reduces tumor size by 83% in subcutaneous xenograft mouse using Panc-1 human pancreatic ductal adenocarcinoma cells. Biperiden lactate (intraperitoneal injection, 8 mg/kg, every 8 hours, 10 days) can reduce frequency of spontaneous seizures and extracellular hippocampal glutamate levels while cause a long-term decrease in hippocampal excitability.Animal Model:Subcutaneous xenograft mouse using Panc-1 human pancreatic ductal adenocarcinoma cells
Dosage:10 mg/kg
Administration:Intraperitoneal injection; everyday; 3 weeks
Result:Tumor size reduced by 83%.
Animal Model:Male Wistar rats (200-250 g)
Dosage:8 mg/kg
Administration:Intraperitoneal injection; every 8 hours; 10 days
Result:Reduced late seizures by about three times with no affecting emotional memory damage
体外研究：
Biperiden lactate (29.6 μg/ml, 72 hours) can significantly induce apoptosis and inhibit proliferation at high doses in human pancreatic ductal adenocarcinoma cells.
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