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编 号:F574313
分子式:C15H24N4O6
分子量:356.37
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生物活性:
Valopicitabine (NM283) is a nucleoside analog and the orally bioavailable proagent of the potent anti-HCV agent 2'-C-methylcytidine (NM107). NM107competitively inhibits NS5B polymerase, causing chain termination.

体内研究:
Valopicitabine (NM283) (100 mg/kg; oral administration; Sprague-Dawley Rats) shows theCmax, AUC, t1/2, and tmax were 3.624 μg/mL, 8.95 μg h/mL, 0.64 hours and 1 hour, respectively.
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