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编 号：F573379
分子式：C18H36N4O11
分子量：484.5
分子式：C18H36N4O11
分子量：484.5
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CAS No: 59-01-8
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生物活性：
Kanamycin (Kanamycin A) is an orally active antibacterial (gram-negative/positive bacteria) agent, inhibits translocation and causes misencoding by binding to the 70 S ribosomal subunit. Kanamycin shows good inhibitory activity to both M. tuberculosis (sensitive and drug-resistant ) and K. pneumonia, which can be used in studies of tuberculosis and pneumonia.
体内研究：
Kanamycin (2, 4 mg/kg; s.c.; once daily, 6 times a week for 3 weeks) inhibits growth of bovine tubercle bacilli in lung and spleen of mice.Kanamycin (1.25, 5 mg/kg; s.c.; single (at 3 h after infection)) inhibits the multiplication of K. pneumonia DT-S in lung, trachea, and blood of mice and in proportion to the dose administration, and also increases the survival rate of mice.Animal Model:Inbred strain normal mice (14-16 g; bovine tubercle bacilli (Ravenel strain) infected model).
Dosage:2, 4 mg/kg
Administration:Subcutaneous injection; once daily, 6 times a week for 3 weeks.
Result:Exerted a marked effect to inhibit the multiplication of the tuberculosis in vivo, especially in the lung of mice.
Animal Model:Slc:ICR male mice (4-week-old; 18-24 g; K. pneumonia DT-S infection model (by the aerosol method)).
Dosage:1.25, 5 mg/kg
Administration:Subcutaneous administration; single (at 3 h after infection).
Result:Suppressed the growth of K. pneumonia DT-S in lung, trachea, and blood in proportion to the dose administration.Resulted in 90% survival at 6 days after infection (negative control group: all died within 4 days), and cleared the K. pneumonia DT-S from lung, trachea, and blood of mice within 48 h (when dosage at 5 mg/kg).
体外研究：
Kanamycin (0.1-100 μg/mL; 2 weeks) exhibits good antibacterial activity (MIC=1-5 μg/mL) to various strains of mycobacteria in vitro.
Kanamycin (Kanamycin A) is an orally active antibacterial (gram-negative/positive bacteria) agent, inhibits translocation and causes misencoding by binding to the 70 S ribosomal subunit. Kanamycin shows good inhibitory activity to both M. tuberculosis (sensitive and drug-resistant ) and K. pneumonia, which can be used in studies of tuberculosis and pneumonia.
体内研究：
Kanamycin (2, 4 mg/kg; s.c.; once daily, 6 times a week for 3 weeks) inhibits growth of bovine tubercle bacilli in lung and spleen of mice.Kanamycin (1.25, 5 mg/kg; s.c.; single (at 3 h after infection)) inhibits the multiplication of K. pneumonia DT-S in lung, trachea, and blood of mice and in proportion to the dose administration, and also increases the survival rate of mice.Animal Model:Inbred strain normal mice (14-16 g; bovine tubercle bacilli (Ravenel strain) infected model).
Dosage:2, 4 mg/kg
Administration:Subcutaneous injection; once daily, 6 times a week for 3 weeks.
Result:Exerted a marked effect to inhibit the multiplication of the tuberculosis in vivo, especially in the lung of mice.
Animal Model:Slc:ICR male mice (4-week-old; 18-24 g; K. pneumonia DT-S infection model (by the aerosol method)).
Dosage:1.25, 5 mg/kg
Administration:Subcutaneous administration; single (at 3 h after infection).
Result:Suppressed the growth of K. pneumonia DT-S in lung, trachea, and blood in proportion to the dose administration.Resulted in 90% survival at 6 days after infection (negative control group: all died within 4 days), and cleared the K. pneumonia DT-S from lung, trachea, and blood of mice within 48 h (when dosage at 5 mg/kg).
体外研究：
Kanamycin (0.1-100 μg/mL; 2 weeks) exhibits good antibacterial activity (MIC=1-5 μg/mL) to various strains of mycobacteria in vitro.
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