产品
编 号：F001089
分子式：C20H16FN3O2
分子量：349.36
分子式：C20H16FN3O2
分子量：349.36
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CAS No: 1001083-74-4
产品详情
生物活性：
APcK110 is a potent Kit inhibitor that can be used for the research of acute myeloid leukemia (AML). APcK110 induces AML cell apoptosis.
体内研究：
APcK110 (500 nM; i.p.; every other day for 60 days) 在小鼠中显示抗 AML 活性。Animal Model:Eight-weeks-old female NODSCID mice, OCI/AML3 xenograft mouse model
Dosage:500 nM
Administration:Intraperitoneal injection, every other day for 60 days
Result:Survival of compound-treated mice was significantly longer compared with mice injected with PBS.
体外研究：
APcK110 (0-500 nM; 0-72 h) 抑制 AML 细胞活力和增殖。APcK110 优先抑制 KIT 突变的 BaF3 细胞株。APcK110 (0-500 nM; 30 min) 抑制 Kit、Stat3、Stat5 和 Akt 的磷酸化。APcK110 (500 nM; overnight) 诱导 OCI/AML3 细胞 caspase 依赖性凋亡。APcK110 (50-500 nM; 7 days) 抑制 AML 原细胞集落形成细胞增殖。
APcK110 is a potent Kit inhibitor that can be used for the research of acute myeloid leukemia (AML). APcK110 induces AML cell apoptosis.
体内研究：
APcK110 (500 nM; i.p.; every other day for 60 days) 在小鼠中显示抗 AML 活性。Animal Model:Eight-weeks-old female NODSCID mice, OCI/AML3 xenograft mouse model
Dosage:500 nM
Administration:Intraperitoneal injection, every other day for 60 days
Result:Survival of compound-treated mice was significantly longer compared with mice injected with PBS.
体外研究：
APcK110 (0-500 nM; 0-72 h) 抑制 AML 细胞活力和增殖。APcK110 优先抑制 KIT 突变的 BaF3 细胞株。APcK110 (0-500 nM; 30 min) 抑制 Kit、Stat3、Stat5 和 Akt 的磷酸化。APcK110 (500 nM; overnight) 诱导 OCI/AML3 细胞 caspase 依赖性凋亡。APcK110 (50-500 nM; 7 days) 抑制 AML 原细胞集落形成细胞增殖。
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