产品
编 号：F572984
分子式：C21H40N8O6
分子量：500.59
分子式：C21H40N8O6
分子量：500.59
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CAS No: 56767-30-7
产品详情
生物活性：
Kentsin, a contraceptive tetrapeptide, is originally extracted from hamster embryos. Kentsin prevents the maturation of Graafian follicles and consequently inhibits ovulation. Kentsin has opiate properties on gastrointestinal motility.
体内研究：
Kentsin (0-100 μg, i.c.v. or intrathecal administration) produces analgesia in both the hotplate and abdominal stretch tests.Kentsin (20 and 100 ng/kg, i.c.v.) inhibits the antral motility index and disrupts the jejunal migrating motor complex in fasted dogs.Kentsin (4.0 μg/kg, i.c.v. 2 hours after the beginning of a meal) restores the “fasted” (the migrating myoelectric complex of intestinal motility), and can be blocked by previous Naloxone (400 μg/kg, i.c.v.).Animal Model:Fasted dogs
Dosage:20 and 100 ng/kg
Administration:Intracerebroventricular injection (i.c.v.)
Result:Inhibited the antral motility index by 51.2 and 76.1%.Disrupted the jejunal migrating motor complex for 2 and 4 h respectively.
体外研究：
Kentsin (100 μg/mL, 18 h) increases endogenous xenotropic virus expression in K-Balb 19a/h cells transformed with Kirsten sarcoma virus.Kentsin (30 μM) does not inhibit electrically stimulated contractions of the guinea pig ileum (GPI) or mouse vas deferens (MVD).
Kentsin, a contraceptive tetrapeptide, is originally extracted from hamster embryos. Kentsin prevents the maturation of Graafian follicles and consequently inhibits ovulation. Kentsin has opiate properties on gastrointestinal motility.
体内研究：
Kentsin (0-100 μg, i.c.v. or intrathecal administration) produces analgesia in both the hotplate and abdominal stretch tests.Kentsin (20 and 100 ng/kg, i.c.v.) inhibits the antral motility index and disrupts the jejunal migrating motor complex in fasted dogs.Kentsin (4.0 μg/kg, i.c.v. 2 hours after the beginning of a meal) restores the “fasted” (the migrating myoelectric complex of intestinal motility), and can be blocked by previous Naloxone (400 μg/kg, i.c.v.).Animal Model:Fasted dogs
Dosage:20 and 100 ng/kg
Administration:Intracerebroventricular injection (i.c.v.)
Result:Inhibited the antral motility index by 51.2 and 76.1%.Disrupted the jejunal migrating motor complex for 2 and 4 h respectively.
体外研究：
Kentsin (100 μg/mL, 18 h) increases endogenous xenotropic virus expression in K-Balb 19a/h cells transformed with Kirsten sarcoma virus.Kentsin (30 μM) does not inhibit electrically stimulated contractions of the guinea pig ileum (GPI) or mouse vas deferens (MVD).
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