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编 号：F572541
分子式：C34H35N3O10
分子量：645.66
分子式：C34H35N3O10
分子量：645.66
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CAS No: 54083-22-6
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生物活性：
Zorubicin (Rubidazon) is a derivative of Daunorubicin (HY-13062A). Zorubicin interacts with topoisomerase II and inhibits DNA polymerases. Zorubicin can be used for the research of acute leukemias and sarcomas.
体内研究：
Zorubicin (12-18 mg/kg; i.p. 48 h after tumour cells injection) affects leukaemic colony forming units.Zorubicin (0.75-6.0 mg/kg; i.v.) increases plasma histamine concentrations and produces immediate hypotension in anesthetized beagle dogs.Animal Model:Six- to eight-week-old male DBA2 mice with P388 tumour cells
Dosage:12-18 mg/kg
Administration:Intraperitoneal injection ; 12-18 mg/kg; 48 h after tumour cells injection
Result:Showed a D1/2 value of 1.6 mg/kg for leukaemic colony forming units.
体外研究：
Zorubicin (0.1-1 μg/mL; 0-24 h) affects cell cycle.Zorubicin (0-128 nM/mL; 20 min) dose-dependently inhibits DNA polymerases α and β, and shows preferential inhibition of polymerase α.
Zorubicin (Rubidazon) is a derivative of Daunorubicin (HY-13062A). Zorubicin interacts with topoisomerase II and inhibits DNA polymerases. Zorubicin can be used for the research of acute leukemias and sarcomas.
体内研究：
Zorubicin (12-18 mg/kg; i.p. 48 h after tumour cells injection) affects leukaemic colony forming units.Zorubicin (0.75-6.0 mg/kg; i.v.) increases plasma histamine concentrations and produces immediate hypotension in anesthetized beagle dogs.Animal Model:Six- to eight-week-old male DBA2 mice with P388 tumour cells
Dosage:12-18 mg/kg
Administration:Intraperitoneal injection ; 12-18 mg/kg; 48 h after tumour cells injection
Result:Showed a D1/2 value of 1.6 mg/kg for leukaemic colony forming units.
体外研究：
Zorubicin (0.1-1 μg/mL; 0-24 h) affects cell cycle.Zorubicin (0-128 nM/mL; 20 min) dose-dependently inhibits DNA polymerases α and β, and shows preferential inhibition of polymerase α.
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