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编 号：F572087
分子式：C15H17NS2
分子量：275.43
分子式：C15H17NS2
分子量：275.43
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CAS No: 5169-78-8
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Tipepidine reversibly inhibits dopamine (DA) D2 receptor-mediated GIRK currents (IDA(GIRK)) with an IC50 of 7.0 μM. Tipepidine subsequently activates VTA dopamine neuron. Tipepidine, a non-narcotic antitussive, exerts an antidepressant-like effect.
体内研究：
Tipepidine (i.p.; 10-40 mg/kg; 0.5-23 hours) significantly decreases the immobility time in the forced swimming test in ACTH-treated rats. Tipepidine (i.p.; 40 mg/kg) increases the extracellular dopamine level of the nucleus accumbens (NAc) in ACTH-treated rats.Animal Model:Male Wistar rats weighting 150-240 g (5-7 weeks old)
Dosage:10, 20 and 40 mg/kg.
Administration:I.p.; 0.5, 5, 23 hours.
Result:Decreased the immobility time in the forced swimming test in ACTH-treated rats.
Tipepidine reversibly inhibits dopamine (DA) D2 receptor-mediated GIRK currents (IDA(GIRK)) with an IC50 of 7.0 μM. Tipepidine subsequently activates VTA dopamine neuron. Tipepidine, a non-narcotic antitussive, exerts an antidepressant-like effect.
体内研究：
Tipepidine (i.p.; 10-40 mg/kg; 0.5-23 hours) significantly decreases the immobility time in the forced swimming test in ACTH-treated rats. Tipepidine (i.p.; 40 mg/kg) increases the extracellular dopamine level of the nucleus accumbens (NAc) in ACTH-treated rats.Animal Model:Male Wistar rats weighting 150-240 g (5-7 weeks old)
Dosage:10, 20 and 40 mg/kg.
Administration:I.p.; 0.5, 5, 23 hours.
Result:Decreased the immobility time in the forced swimming test in ACTH-treated rats.
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