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编 号:F570326
分子式:C11H12N2O3
分子量:220.23
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生物活性:
D-5-Hydroxytryptophan (D-5-HTP) is the D-isomer of 5-HTP and can be isolated from DL-5-hydroxytryptophan by continuous separation. Compared with intraperitoneal administration of L-5-Hydroxytryptophan, which can induce dose-dependent backward walking behavior in mice, D-5-Hydroxytryptophan has no significant effect on mouse behavior and is a negative control. D-5-Hydroxytryptophan is also a 5-HT ligand, capable of binding to the 5-HT site with affinity in the micromolar range.

体内研究:
D-5-Hydroxytryptophan (100, 320 mg/kg; ip; 单剂量) 不能诱导小鼠向后行走的行为,而 L-5-Hydroxytryptophan 则可以诱导。
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