产品
编 号:F564954
分子式:C22H28F3N7
分子量:447.5
产品类型
结构图
CAS No: 2342583-66-6
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产品详情
生物活性:
NCC007 is a dual casein kinase Iα (CKIα) and δ (CKIδ) inhibitor with IC50s of 1.8 and 3.6 μM, respectively. NCC007 can be used in research of modulating mammalian circadian rhythms.
体内研究:
NCC007 (5-15 mM, infused into the lateral ventricle) controls circadian rhythms through CKI inhibition.Animal Model:Adult C57BL/6J background male mice (8 weeks old)
Dosage:5, 15 mM
Administration:Infused into the lateral ventricle, constant dark condition
Result:Showed more period lengthening effect with 0.15 hours at 5 mM and 15 mM.