产品
编 号：F563140
分子式：C28H29NO6
分子量：475.53
分子式：C28H29NO6
分子量：475.53
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
50mg
询价
询价
100mg
询价
询价
结构图
CAS No: 2059952-75-7
产品详情
生物活性：
STAT3-IN-1 (compound 7d) is an excellent, selective and orally active STAT3 inhibitor, with IC50 values of 1.82 μM and 2.14 μM in HT29 and MDA-MB 231 cells, respectively. STAT3-IN-1 (compound 7d) induces tumor cells apoptosis.
体内研究：
STAT3-IN-1 (化合物 7d：10、20 mg/kg，两周) 在小鼠异种移植模型中以低毒性阻止肿瘤生长。Animal Model:Mouse-xenograft model bearing inoculation of mice breast cancer 4T1 cells.
Dosage:10, 20 mg/kg.
Administration:Oral administration once every other day for two weeks.
Result: Arrested tumor growth with no obvious body weight loss.
体外研究：
STAT3-IN-1 (compound 7d：0-10 μM，48 h) 抑制STAT3 685位赖氨酸乙酰化并影响其特定基因表达。 STAT3-IN-1 (compound 7d：0-10 μM，48 h) 在MDA-MB-231细胞中诱导肿瘤细胞凋亡。
STAT3-IN-1 (compound 7d) is an excellent, selective and orally active STAT3 inhibitor, with IC50 values of 1.82 μM and 2.14 μM in HT29 and MDA-MB 231 cells, respectively. STAT3-IN-1 (compound 7d) induces tumor cells apoptosis.
体内研究：
STAT3-IN-1 (化合物 7d：10、20 mg/kg，两周) 在小鼠异种移植模型中以低毒性阻止肿瘤生长。Animal Model:Mouse-xenograft model bearing inoculation of mice breast cancer 4T1 cells.
Dosage:10, 20 mg/kg.
Administration:Oral administration once every other day for two weeks.
Result: Arrested tumor growth with no obvious body weight loss.
体外研究：
STAT3-IN-1 (compound 7d：0-10 μM，48 h) 抑制STAT3 685位赖氨酸乙酰化并影响其特定基因表达。 STAT3-IN-1 (compound 7d：0-10 μM，48 h) 在MDA-MB-231细胞中诱导肿瘤细胞凋亡。
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备