产品
编 号：F558204
分子式：C28H41NO9
分子量：535.63
分子式：C28H41NO9
分子量：535.63
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 1426953-21-0
产品详情
生物活性：
Thailanstatin A is an ultra-potent inhibitor of eukaryotic RNA splicing (IC50=650 nM). Thailanstatin A exerts effects via non-covalent binding to the SF3b subunit of the U2 snRNA subcomplex of the spliceosome and shows low-nM to sub-nM IC50s against multiple cancer cell lines. Thailanstatin A, a payload for ADCs, is conjugated to the lysines on trastuzumab yielding “linker-less” ADC.
体外研究：
Thailanstatin A (TST-A) 是一种有效的抗增殖天然产物，可以从 Burkholderia thailandensis MSMB43 中发现。 Thailanstatin A (DU-145，NCI-H232A、MDA-MB-231 和 SKOV-3 细胞) 表现出有效的抗增殖活性，GI50s 值为 1.11-2.69 nM。
Thailanstatin A is an ultra-potent inhibitor of eukaryotic RNA splicing (IC50=650 nM). Thailanstatin A exerts effects via non-covalent binding to the SF3b subunit of the U2 snRNA subcomplex of the spliceosome and shows low-nM to sub-nM IC50s against multiple cancer cell lines. Thailanstatin A, a payload for ADCs, is conjugated to the lysines on trastuzumab yielding “linker-less” ADC.
体外研究：
Thailanstatin A (TST-A) 是一种有效的抗增殖天然产物，可以从 Burkholderia thailandensis MSMB43 中发现。 Thailanstatin A (DU-145，NCI-H232A、MDA-MB-231 和 SKOV-3 细胞) 表现出有效的抗增殖活性，GI50s 值为 1.11-2.69 nM。
产品资料
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