产品
编 号：F554880
分子式：C13H8Cl2N4OS
分子量：339.2
分子式：C13H8Cl2N4OS
分子量：339.2
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
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5mg
询价
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10mg
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25mg
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结构图
CAS No: 1257423-87-2
产品详情
生物活性：
BTdCPU is a potent heme regulated inhibitor kinase (HRI) activator that promotes eIF2α phosphorylation and induces apoptosis in Dexamethasone (HY-14648) (Dex)-resistant cancer cells. BTdCPU can be used in the study of cancers such as multiple myeloma and Dex-resistant multiple myeloma.
体内研究：
BTdCPU (175 mg/kg；腹腔注射；每日一次，持续 21 天) 在小鼠异种移植乳腺肿瘤模型中抑制肿瘤生长而无毒性。Animal Model:Female nude mice (mice xenograft breast tumors model).
Dosage:175 mg/kg
Administration:Intraperitoneal injection; single daily for 21 days
Result:Led to complete tumor stasis,which persisted for the remainder of the 3-week studyShowed good safety in mice.
体外研究：
BTdCPU (10 μM；4，8 h) BTdCPU 在 MM 细胞中诱导 eIF2α 的磷酸化并促进细胞死亡。 BTdCPU (10 μM；4，8 h) 对 dex 抗性原代 MM 细胞有细胞毒性。
BTdCPU is a potent heme regulated inhibitor kinase (HRI) activator that promotes eIF2α phosphorylation and induces apoptosis in Dexamethasone (HY-14648) (Dex)-resistant cancer cells. BTdCPU can be used in the study of cancers such as multiple myeloma and Dex-resistant multiple myeloma.
体内研究：
BTdCPU (175 mg/kg；腹腔注射；每日一次，持续 21 天) 在小鼠异种移植乳腺肿瘤模型中抑制肿瘤生长而无毒性。Animal Model:Female nude mice (mice xenograft breast tumors model).
Dosage:175 mg/kg
Administration:Intraperitoneal injection; single daily for 21 days
Result:Led to complete tumor stasis,which persisted for the remainder of the 3-week studyShowed good safety in mice.
体外研究：
BTdCPU (10 μM；4，8 h) BTdCPU 在 MM 细胞中诱导 eIF2α 的磷酸化并促进细胞死亡。 BTdCPU (10 μM；4，8 h) 对 dex 抗性原代 MM 细胞有细胞毒性。
产品资料
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