产品
编 号:F554764
分子式:C37H44BrO4P
分子量:663.62
产品类型
结构图
CAS No: 1254044-38-6
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产品详情
生物活性:
Mito-apocynin (C11), an orally active mitochondria-targeted triphenylphosphonium (TPP)-based compound, is synthesized by conjugating the Apocynin moiety with a TPP+ cation. Mito-apocynin (C11) selectively targets mitochondria, and shows neuroprotective effect. Mito-apocynin (C11) prevents hyposmia and corrects deficits in motor function.
体内研究:
Mito-apocynin-C11 (3 mg/kg;口服强饲;3 次/周,从 3 个月大到 15 个月) 显著改善 LRRK2R1441G 小鼠的协调运动功能和嗅觉功能。Animal Model:LRRK2R1441G mice
Dosage:3 mg/kg
Administration:Oral gavage; 3x/wk from 3 months of age until 15 months
Result:Markedly improved the coordinated motor function and olfactory function.