产品
编 号：F554750
分子式：C30H48O2
分子量：440.7
分子式：C30H48O2
分子量：440.7
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CAS No: 1252676-55-3
产品详情
生物活性：
Waltonitone is a ursane-type pentacyclic triterpene isolated from Gentian waltonii Burkill. Waltonitone significantly inhibits hepatocellular carcinoma cells growth and induces apoptosis in vitro and in vivo.
体内研究：
Waltonitone (i.v.; 20 mg/kg or 50 mg/kg; once every two days for 16 days) inhibits BEL-7402 tumor growth in male athymic mice (BALB/c nu/nu) in vivo.
体外研究：
waltonitone (10 μM, 25 μM; for 48 hours) results in an increment of sub-G1 population in BEL-7402 cells. Waltonitone (25 μM; for 48 hours) induces BEL-7402 cells apoptosis. Waltonitone (25 μM; for 48 hours) can effectively activate caspase-3 in BEL-7402 cells.
Waltonitone is a ursane-type pentacyclic triterpene isolated from Gentian waltonii Burkill. Waltonitone significantly inhibits hepatocellular carcinoma cells growth and induces apoptosis in vitro and in vivo.
体内研究：
Waltonitone (i.v.; 20 mg/kg or 50 mg/kg; once every two days for 16 days) inhibits BEL-7402 tumor growth in male athymic mice (BALB/c nu/nu) in vivo.
体外研究：
waltonitone (10 μM, 25 μM; for 48 hours) results in an increment of sub-G1 population in BEL-7402 cells. Waltonitone (25 μM; for 48 hours) induces BEL-7402 cells apoptosis. Waltonitone (25 μM; for 48 hours) can effectively activate caspase-3 in BEL-7402 cells.
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