产品
编 号:F550507
分子式:C11H15Cl2N3O2S
分子量:324.23
产品类型
结构图
CAS No: 116700-36-8
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产品详情
生物活性:
H-9 Dihydrochloride is a PKA (protein kinase) inhibitor. H-9 Dihydrochloride (10 μM) significantly reduces the excitatory response to 5-HT. H-9 Dihydrochloride also has a direct effect on pharyngeal activity. H-9 Dihydrochloride inhibits signal-transduction and cell growth in EGF (epidermal growth factor)-dependent epithelial cell lines.
体内研究:
H-9 Dihydrochloride microperfusion (100 μM) prevents picrotoxin seizures in 50% of the animals and significantly reduced the mean number of seizures and mean seizure duration.
体外研究:
H-9 Dihydrochloride significantly inhibits A431 cells.H-9 Dihydrochloride inhibits more effectively cyclic nucleotide-dependent protein kinases than other kinases.