产品
编 号：F546693
分子式：C21H28O5
分子量：360.44
分子式：C21H28O5
分子量：360.44
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
100mg
询价
询价
500mg
询价
询价
结构图
CAS No: 53-06-5
产品详情
生物活性：
Cortisone (17-Hydroxy-11-dehydrocorticosterone), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acts as an immunosuppressant and anti-inflammatory agent. Cortisone can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations.
体内研究：
Cortisone (2 mg/kg; i.m. on alternate days for 2 months) decreases the BCG (the vaccine strain of tubercle bacillus) lesions and tuberculin reactions in rabbits.Animal Model:Male New Zealand white rabbits (2.1-2.4 kg) were injected with BCG at six days after the first administrtion
Dosage:2 mg/kg
Administration:Intramuscular injection on alternate days for 2 months
Result:Reduced the BCG lesions and tuberculin reactions.Reduced the number of infiltrating mononuclear cells (MN), the amount of caseous necrosis and ulceration, and the percent of NM that were beta-galactosidase-positive.
体外研究：
Cortisone (2.8-28,000 nM) dose-dependently attenuates the apoptosis induced by Cortisol in peripheral-blood mononuclear cells (PBMCs).
Cortisone (17-Hydroxy-11-dehydrocorticosterone), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acts as an immunosuppressant and anti-inflammatory agent. Cortisone can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations.
体内研究：
Cortisone (2 mg/kg; i.m. on alternate days for 2 months) decreases the BCG (the vaccine strain of tubercle bacillus) lesions and tuberculin reactions in rabbits.Animal Model:Male New Zealand white rabbits (2.1-2.4 kg) were injected with BCG at six days after the first administrtion
Dosage:2 mg/kg
Administration:Intramuscular injection on alternate days for 2 months
Result:Reduced the BCG lesions and tuberculin reactions.Reduced the number of infiltrating mononuclear cells (MN), the amount of caseous necrosis and ulceration, and the percent of NM that were beta-galactosidase-positive.
体外研究：
Cortisone (2.8-28,000 nM) dose-dependently attenuates the apoptosis induced by Cortisol in peripheral-blood mononuclear cells (PBMCs).
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