产品
编 号：F546681
分子式：C13H18N4O3
分子量：278.31
分子式：C13H18N4O3
分子量：278.31
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
500mg
询价
询价
1g
询价
询价
结构图
CAS No: 6493-05-6
产品详情
生物活性：
Pentoxifylline (BL-191), a haemorheological agent, is an orally active non-selective phosphodiesterase (PDE) inhibitor, with immune modulation, anti-inflammatory, hemorheological, anti-fibrinolytic and anti-proliferation effects. Pentoxifylline can be used for the research of peripheral vascular disease, cerebrovascular disease and a number of other conditions involving a defective regional microcirculation.
体内研究：
Pentoxifylline (200 mg/kg; i.p.) has a protective effect on rats with transient global ischemia and reduces cognitive impairment.Animal Model:Adult male Wistar rats 12-13-weeks-old (250-300 g)
Dosage:200 mg/kg
Administration:Intraperitoneal injection, at 1hr before and 3 hr after ischemia
Result:Significantly improved the spatial memory and effects were significant different from those of sham-operated and vehicle groups.
体外研究：
Pentoxifylline (0.1-50 mM; 24-48 hours) inhibits cell proliferation in a dose-dependent manner.Pentoxifylline (0.5 mM; 12-36 hours) increases apoptosis and decreases autophagy levels in MDA-MB-231 cells.Pentoxifylline (0.5 mM; 12-36 hours) induces autophagy in MDA-MB-231 cells.Pentoxifylline (0.5 mM; 24-48 hours) blocks cell cycle at the G0/G1 phase.Pentoxifylline results in high LC3-II/LC3-ratio.
Pentoxifylline (BL-191), a haemorheological agent, is an orally active non-selective phosphodiesterase (PDE) inhibitor, with immune modulation, anti-inflammatory, hemorheological, anti-fibrinolytic and anti-proliferation effects. Pentoxifylline can be used for the research of peripheral vascular disease, cerebrovascular disease and a number of other conditions involving a defective regional microcirculation.
体内研究：
Pentoxifylline (200 mg/kg; i.p.) has a protective effect on rats with transient global ischemia and reduces cognitive impairment.Animal Model:Adult male Wistar rats 12-13-weeks-old (250-300 g)
Dosage:200 mg/kg
Administration:Intraperitoneal injection, at 1hr before and 3 hr after ischemia
Result:Significantly improved the spatial memory and effects were significant different from those of sham-operated and vehicle groups.
体外研究：
Pentoxifylline (0.1-50 mM; 24-48 hours) inhibits cell proliferation in a dose-dependent manner.Pentoxifylline (0.5 mM; 12-36 hours) increases apoptosis and decreases autophagy levels in MDA-MB-231 cells.Pentoxifylline (0.5 mM; 12-36 hours) induces autophagy in MDA-MB-231 cells.Pentoxifylline (0.5 mM; 24-48 hours) blocks cell cycle at the G0/G1 phase.Pentoxifylline results in high LC3-II/LC3-ratio.
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