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编 号：F546653
分子式：C16H18N2O5S
分子量：350.39
分子式：C16H18N2O5S
分子量：350.39
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CAS No: 87-08-1
产品详情
生物活性：
Penicillin V (Phenoxymethylpenicillin) is a potent and orally active antibiotic. Penicillin V shows antibacterial activity for Streptococci, Clostridium difficile and staphylococcus aureus. Penicillin V has the potential for the research of otitis, sinusitis, pharyngitis and tonsillitis.
体内研究：
Penicillin V (0.063-0.25 mg/kg; s.c.) inhibits the outgrowth of S. aureus in mice thigh muscle.Penicillin V (2 mg/kg; s.c.) exhibits the plasma half-life (61 min) and mean AUC (0.47 mg/L·h).Penicillin V (100 mg/kg; p.o. once daily for 5 d) avoids the fulminant infection of acute purulent otitis media (AOM) in rats.Animal Model:Specific pathogen free (SPF) male Swiss mice (20-25 g) are inoculated S. aureus
Dosage:0.063, 0.13, 0.25 mg/kg
Administration:S.c.
Result:Decreased the number of CFU (1.34×107 counts/mL) compared to controls (3.5×107 counts/mL) at the dose of 0.25 mg/kg.
体外研究：
Penicillin V (0.002-8.0 mg/L) inhibits the growth of Streptococci, with the minimum inhibitory concentrations (MICs) of 0.004-0.008 mg/L.Penicillin V (0.002-8.0 mg/L) shows antibacterial activity for Clostridium difficile with an MIC50 value of 4.0 mg/L and an MIC90 value of 8.0 mg/L.Penicillin V (0.004-0.063 mg/L; 18 h) inhibits the growth of Staphylococcus aureus, with an MIC value of 0.016 mg/L.
Penicillin V (Phenoxymethylpenicillin) is a potent and orally active antibiotic. Penicillin V shows antibacterial activity for Streptococci, Clostridium difficile and staphylococcus aureus. Penicillin V has the potential for the research of otitis, sinusitis, pharyngitis and tonsillitis.
体内研究：
Penicillin V (0.063-0.25 mg/kg; s.c.) inhibits the outgrowth of S. aureus in mice thigh muscle.Penicillin V (2 mg/kg; s.c.) exhibits the plasma half-life (61 min) and mean AUC (0.47 mg/L·h).Penicillin V (100 mg/kg; p.o. once daily for 5 d) avoids the fulminant infection of acute purulent otitis media (AOM) in rats.Animal Model:Specific pathogen free (SPF) male Swiss mice (20-25 g) are inoculated S. aureus
Dosage:0.063, 0.13, 0.25 mg/kg
Administration:S.c.
Result:Decreased the number of CFU (1.34×107 counts/mL) compared to controls (3.5×107 counts/mL) at the dose of 0.25 mg/kg.
体外研究：
Penicillin V (0.002-8.0 mg/L) inhibits the growth of Streptococci, with the minimum inhibitory concentrations (MICs) of 0.004-0.008 mg/L.Penicillin V (0.002-8.0 mg/L) shows antibacterial activity for Clostridium difficile with an MIC50 value of 4.0 mg/L and an MIC90 value of 8.0 mg/L.Penicillin V (0.004-0.063 mg/L; 18 h) inhibits the growth of Staphylococcus aureus, with an MIC value of 0.016 mg/L.
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