产品
编 号：F006300
分子式：C14H10ClN3S2
分子量：319.83
分子式：C14H10ClN3S2
分子量：319.83
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
结构图
CAS No: 101530-10-3
产品详情
生物活性：
Lanoconazole is a potent and orally active imidazole antifungal agent, shows a broad spectrum of activity against fungi?in vitro?and?in vivo. Lanoconazole interferes with ergosterol biosynthesis by inhibiting sterol 14-alpha demethylase and blocking fungal membrane ergosterol biosynthesis. Lanoconazole can be used for the investigation of dermatophytosis and onychomycosis.
体内研究：
Lanoconazole (处理耳部；0.3%-3%；6 天) 剂量依赖性地抑制 TPA 诱导的刺激性皮炎，抑制中性粒细胞趋化因子 (如角质形成细胞衍生趋化因子和巨噬细胞炎症蛋白-2) 的产生，并抑制中性粒细胞浸润到炎症部位。 Lanoconazole (口服；3、10 或30 mg/kg；每天一次；3 周) 显著抑制新型隐球菌与正常小鼠的盐水对照相比。此外，它显著降低了新型隐球菌的增长。MAIDS 小鼠肺和脑中的新型隐球菌。Animal Model:BALB/c mice
Dosage:0.3%-3% dosage
Administration:Treatment for ear
Result:Exhibited an inhibition effect of LCZ on ear swelling induced by topical application of TPA in mice.
Animal Model:Four week old C57BL/6 mice infected intraperitoneally with LP-BM5 murine leukaemia virus
Dosage:3, 10 or 30 mg/kg
Administration:Oral adminstration
Result:Inhibited C. neoformans? growth in both normal and C. neoformans?-induced encephalitis MAIDS mice .
Lanoconazole is a potent and orally active imidazole antifungal agent, shows a broad spectrum of activity against fungi?in vitro?and?in vivo. Lanoconazole interferes with ergosterol biosynthesis by inhibiting sterol 14-alpha demethylase and blocking fungal membrane ergosterol biosynthesis. Lanoconazole can be used for the investigation of dermatophytosis and onychomycosis.
体内研究：
Lanoconazole (处理耳部；0.3%-3%；6 天) 剂量依赖性地抑制 TPA 诱导的刺激性皮炎，抑制中性粒细胞趋化因子 (如角质形成细胞衍生趋化因子和巨噬细胞炎症蛋白-2) 的产生，并抑制中性粒细胞浸润到炎症部位。 Lanoconazole (口服；3、10 或30 mg/kg；每天一次；3 周) 显著抑制新型隐球菌与正常小鼠的盐水对照相比。此外，它显著降低了新型隐球菌的增长。MAIDS 小鼠肺和脑中的新型隐球菌。Animal Model:BALB/c mice
Dosage:0.3%-3% dosage
Administration:Treatment for ear
Result:Exhibited an inhibition effect of LCZ on ear swelling induced by topical application of TPA in mice.
Animal Model:Four week old C57BL/6 mice infected intraperitoneally with LP-BM5 murine leukaemia virus
Dosage:3, 10 or 30 mg/kg
Administration:Oral adminstration
Result:Inhibited C. neoformans? growth in both normal and C. neoformans?-induced encephalitis MAIDS mice .
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