产品
编 号：F546570
分子式：C28H37ClO7
分子量：521.04
分子式：C28H37ClO7
分子量：521.04
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
250mg
560
In-stock
结构图
CAS No: 5534-09-8
产品详情
生物活性：
Beclometasone dipropionate, the proagent of Beclometasone, is an orally active and potent glucocorticoid recepter agonist. Beclometasone dipropionate acts via a glucocorticoid receptor and suppresses inflammation and hyperproliferation. Beclometasone dipropionate can be used for asthma .
体内研究：
Beclometasone dipropionate (150 μg/kg; nebulization; male BALB/c mice) relieves asthma and decreases total cell number and relative eosinophil number.Animal Model:Ten-week-old male Balb/c mice.
Dosage:5 mg/kg (100 μg/ml for 60 min).
Administration:Orally at 24 h and 1 h before the LPS aerosol.
Result:Significantly (P < 0.05) inhibited the decrease of IL-10 level in BAL fluid induced by LPS exposure.Markedly reduced the release of both MMP-2 and MMP-9.
Animal Model:Male BALB/c mice with asthma
Dosage:150 μg/kg
Administration:Nebulization
Result:Decreased total cell number and relative eosinophil number in BALF.
体外研究：
Beclometasone dipropionate (1-100 nM; 20 min) inhibits STAT-1 expression and reduces the levels of iNOS, ROS and NT generated by rhIL-17A in 16HBE cells.
Beclometasone dipropionate, the proagent of Beclometasone, is an orally active and potent glucocorticoid recepter agonist. Beclometasone dipropionate acts via a glucocorticoid receptor and suppresses inflammation and hyperproliferation. Beclometasone dipropionate can be used for asthma .
体内研究：
Beclometasone dipropionate (150 μg/kg; nebulization; male BALB/c mice) relieves asthma and decreases total cell number and relative eosinophil number.Animal Model:Ten-week-old male Balb/c mice.
Dosage:5 mg/kg (100 μg/ml for 60 min).
Administration:Orally at 24 h and 1 h before the LPS aerosol.
Result:Significantly (P < 0.05) inhibited the decrease of IL-10 level in BAL fluid induced by LPS exposure.Markedly reduced the release of both MMP-2 and MMP-9.
Animal Model:Male BALB/c mice with asthma
Dosage:150 μg/kg
Administration:Nebulization
Result:Decreased total cell number and relative eosinophil number in BALF.
体外研究：
Beclometasone dipropionate (1-100 nM; 20 min) inhibits STAT-1 expression and reduces the levels of iNOS, ROS and NT generated by rhIL-17A in 16HBE cells.
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