产品
编 号：F546453
分子式：C8H8O2
分子量：136.15
分子式：C8H8O2
分子量：136.15
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5g
100
In-stock
结构图
CAS No: 99-94-5
产品详情
生物活性：
p-Toluic acid (4-Methylbenzoic acid), coumarin, is a substituted benzoic acid. p-Toluic acidis synthetic p-aminomethylbenzoic acid (PAMBA), intermediates such as p-toluonitrile. p-Toluic acidMay have potential reproductive toxicity, press 1g/kgRepeated administration of doses can produce a variety of adverse effects on the epididymis.
体内研究：
在生殖/发育研究中，p-Toluic acid (1 g/kg; po, once daily for 28 days) 会降低大鼠的附睾重量，并增加附睾尾少精子症/无精子症的发生率。0、100、300 或 1,000 mg/kg 剂量下，p-Toluic acid 未显示出对动物生殖器官的任何不利影响，且不会影响发情周期或交配表现。p-Toluic acid 在雄性和雌性大鼠中的 NOEL 被认为是 300 mg/kg。Animal Model:Male and female rats
Dosage: 0, 100, 300, 1,000 mg/kg
Administration:po; once daily for 28 days
Result:Resulted temporal salivation, a slight increase in food consumption and a moderate increase in blood aspartate aminotransferase (AST) activity under 1000 mg/kg dose.NOEL is considered to be 300 mg/kg for male and female rats.
p-Toluic acid (4-Methylbenzoic acid), coumarin, is a substituted benzoic acid. p-Toluic acidis synthetic p-aminomethylbenzoic acid (PAMBA), intermediates such as p-toluonitrile. p-Toluic acidMay have potential reproductive toxicity, press 1g/kgRepeated administration of doses can produce a variety of adverse effects on the epididymis.
体内研究：
在生殖/发育研究中，p-Toluic acid (1 g/kg; po, once daily for 28 days) 会降低大鼠的附睾重量，并增加附睾尾少精子症/无精子症的发生率。0、100、300 或 1,000 mg/kg 剂量下，p-Toluic acid 未显示出对动物生殖器官的任何不利影响，且不会影响发情周期或交配表现。p-Toluic acid 在雄性和雌性大鼠中的 NOEL 被认为是 300 mg/kg。Animal Model:Male and female rats
Dosage: 0, 100, 300, 1,000 mg/kg
Administration:po; once daily for 28 days
Result:Resulted temporal salivation, a slight increase in food consumption and a moderate increase in blood aspartate aminotransferase (AST) activity under 1000 mg/kg dose.NOEL is considered to be 300 mg/kg for male and female rats.
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