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编 号：F546389
分子式：C163H267N51O50S2
分子量：3805.31
分子式：C163H267N51O50S2
分子量：3805.31
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CAS No: 99889-63-1
产品详情
生物活性：
Calcitonin Gene Related Peptide (CGRP) II, rat, a CGRP receptor activator, is a potent and long-lasting vasodilator. Calcitonin Gene Related Peptide (CGRP) II can be used in the research of cardiovascular diseases.
体内研究：
Calcitonin Gene Related Peptide (CGRP) II, rat (rat-βCGRP, bolus injection, 0.3 μg/kg, at 10 min intervals) induces hypotension and vasodilatation in Male Sprague-Dawley rats.Animal Model:Male Sprague-Dawley rats.
Dosage:0.01 ng/kg-3 μg/kg (100 μL), succeeded by a 150 μL isotonic saline flush, at 10 min intervals.
Administration:A bolus injection
Result:Induced PA (pial artery) dilatation and increased in LCBFFlux (local cortical cerebral blood flow).
体外研究：
Calcitonin Gene Related Peptide (CGRP) II, rat induces vasodilator effects in small-diameter pig left anterior descending (LAD) coronary arteries with an EC50 value of 0.56 nM.Calcitonin Gene Related Peptide (CGRP) II, rat relaxes the spontaneous tone in isolated internal anal sphincter (IAS) strips, with an EC50 value of 83 μM.Calcitonin Gene Related Peptide (CGRP) II, rat (rβCGRP) inhibits [125I]hαCGRP binding (IC50: 7 nM), and stimulates cAMP accumulation (EC50: 0.56 nM) in the cells co-expressing mRAMP1 (mouse receptor-activity-modifying-protein 1) and rCRLR (rat calcitonin receptor-like receptor).Calcitonin Gene Related Peptide (CGRP) II, rat (rat-βCGRP, 0.01-100 nM) induces endothelium-independent relaxations in the coronary arteries from male and female Sprague-Dawley rats, with an IC50 value of 2.8 nM approximately.
Calcitonin Gene Related Peptide (CGRP) II, rat, a CGRP receptor activator, is a potent and long-lasting vasodilator. Calcitonin Gene Related Peptide (CGRP) II can be used in the research of cardiovascular diseases.
体内研究：
Calcitonin Gene Related Peptide (CGRP) II, rat (rat-βCGRP, bolus injection, 0.3 μg/kg, at 10 min intervals) induces hypotension and vasodilatation in Male Sprague-Dawley rats.Animal Model:Male Sprague-Dawley rats.
Dosage:0.01 ng/kg-3 μg/kg (100 μL), succeeded by a 150 μL isotonic saline flush, at 10 min intervals.
Administration:A bolus injection
Result:Induced PA (pial artery) dilatation and increased in LCBFFlux (local cortical cerebral blood flow).
体外研究：
Calcitonin Gene Related Peptide (CGRP) II, rat induces vasodilator effects in small-diameter pig left anterior descending (LAD) coronary arteries with an EC50 value of 0.56 nM.Calcitonin Gene Related Peptide (CGRP) II, rat relaxes the spontaneous tone in isolated internal anal sphincter (IAS) strips, with an EC50 value of 83 μM.Calcitonin Gene Related Peptide (CGRP) II, rat (rβCGRP) inhibits [125I]hαCGRP binding (IC50: 7 nM), and stimulates cAMP accumulation (EC50: 0.56 nM) in the cells co-expressing mRAMP1 (mouse receptor-activity-modifying-protein 1) and rCRLR (rat calcitonin receptor-like receptor).Calcitonin Gene Related Peptide (CGRP) II, rat (rat-βCGRP, 0.01-100 nM) induces endothelium-independent relaxations in the coronary arteries from male and female Sprague-Dawley rats, with an IC50 value of 2.8 nM approximately.
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