产品
编 号：F546188
分子式：C19H25NOS
分子量：315.47
分子式：C19H25NOS
分子量：315.47
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
询价
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10mg
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50mg
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100mg
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询价
结构图
CAS No: 99755-59-6
产品详情
生物活性：
Rotigotine is a potent dopamine receptor agonist with Ki values of 0.71?nM, 4-15?nM, and 83?nM for the dopamine D3 receptor and D2, D5, D4 receptors and dopamine D1 receptor. Rotigotine a partial agonist of the 5-HT1A receptor, and an antagonist of the α2B-adrenergic receptor. Rotigotine can be used for parkinson's disease (PD) research.
体内研究：
Rotigotine (0.1-5 mg/kg; i.h.; for 14 days; male Sprague–Dawley rats) has antidepressant effect.Animal Model:Male Sprague–Dawley rats
Dosage:0.1, 0.5, 1, and 5 mg/kg
Administration:Subcutaneous injection; for 14 days.
Result:Had antidepressant effect at a dose of 1 mg/kg or less.
体外研究：
Rotigotine (0.01-10 μM) slightly protects dopaminergic neurons against MPP+ toxicity dopamine, protects dopaminergic neurons against rotenone-induced cell death and significantly inhibits ROS production by rotenone.
Rotigotine is a potent dopamine receptor agonist with Ki values of 0.71?nM, 4-15?nM, and 83?nM for the dopamine D3 receptor and D2, D5, D4 receptors and dopamine D1 receptor. Rotigotine a partial agonist of the 5-HT1A receptor, and an antagonist of the α2B-adrenergic receptor. Rotigotine can be used for parkinson's disease (PD) research.
体内研究：
Rotigotine (0.1-5 mg/kg; i.h.; for 14 days; male Sprague–Dawley rats) has antidepressant effect.Animal Model:Male Sprague–Dawley rats
Dosage:0.1, 0.5, 1, and 5 mg/kg
Administration:Subcutaneous injection; for 14 days.
Result:Had antidepressant effect at a dose of 1 mg/kg or less.
体外研究：
Rotigotine (0.01-10 μM) slightly protects dopaminergic neurons against MPP+ toxicity dopamine, protects dopaminergic neurons against rotenone-induced cell death and significantly inhibits ROS production by rotenone.
产品资料
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