产品
编 号：F545895
分子式：C27H21N3O5
分子量：467.47
分子式：C27H21N3O5
分子量：467.47
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
询价
询价
5mg
询价
询价
结构图
CAS No: 99533-80-9
产品详情
生物活性：
K-252a, a staurosporine analog, inhibits protein kinase, with IC50 values of 470 nM, 140 nM, 270 nM, and 1.7 nM for PKC, PKA, Ca2+/calmodulin-dependent kinase type II, and phosphorylase kinase, respectively. K-252a is a potent inhibitor (IC50 of 3 nM) of the tyrosine protein kinase (TRK) activity of the NGF receptor gp140trk, the product of the trk protooncogene.
体内研究：
K252a (20 mg/kg/day) inhibiting TrkB pathway dampens the neuroprotective effects induced by TH.Animal Model:Mice.
Dosage:20 mg/kg/day.
Administration:Intraperitoneally, daily, for consecutive 5 days.
Result:Dampened the neuroprotective effects induced by TH.
体外研究：
K-252a (3-100 nM, 8d) inhibits NGF-promoted neurite outgrowth.
K-252a, a staurosporine analog, inhibits protein kinase, with IC50 values of 470 nM, 140 nM, 270 nM, and 1.7 nM for PKC, PKA, Ca2+/calmodulin-dependent kinase type II, and phosphorylase kinase, respectively. K-252a is a potent inhibitor (IC50 of 3 nM) of the tyrosine protein kinase (TRK) activity of the NGF receptor gp140trk, the product of the trk protooncogene.
体内研究：
K252a (20 mg/kg/day) inhibiting TrkB pathway dampens the neuroprotective effects induced by TH.Animal Model:Mice.
Dosage:20 mg/kg/day.
Administration:Intraperitoneally, daily, for consecutive 5 days.
Result:Dampened the neuroprotective effects induced by TH.
体外研究：
K-252a (3-100 nM, 8d) inhibits NGF-promoted neurite outgrowth.
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