产品
编 号：F545290
分子式：C25H26O7
分子量：438.47
分子式：C25H26O7
分子量：438.47
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CAS No: 99119-73-0
产品详情
生物活性：
Kushenol C, isolated from the roots of Sophora flavescens, shows anti-Inflammatory and anti-oxidative stress activities. Kushenol C inhibits BACE1 (β-site APP cleaving enzyme 1) with an IC50 of 5.45 μM.
体外研究：
Kushenol C dose-dependently suppresses the production of inflammatory mediators, including NO, PGE2, IL-6, IL1β, MCP-1, and IFN-β in LPS-stimulated RAW264.7 macrophages. Kushenol C (50-100 μM;) significantly decreases the phosphorylation of both STAT1 molecules and STAT6 in a dose-dependent manner in LPS-stimulated RAW264.7 cells.Kushenol C upregulates the expression of HO-1 and its activities in the LPS-stimulated RAW264.7 macrophages. In HaCaT cells, Kushenol C prevents DNA damage and cell death by upregulating the endogenous antioxidant defense system involving glutathione, superoxide dismutase, and catalase, which prevents reactive oxygen species production from tert-butyl hydroperoxide (tBHP)-induced oxidative stress in HaCaT cells. Kushenol C inhibits BChE and AChE with IC50s of 54.86 and 33.13 μM.
Kushenol C, isolated from the roots of Sophora flavescens, shows anti-Inflammatory and anti-oxidative stress activities. Kushenol C inhibits BACE1 (β-site APP cleaving enzyme 1) with an IC50 of 5.45 μM.
体外研究：
Kushenol C dose-dependently suppresses the production of inflammatory mediators, including NO, PGE2, IL-6, IL1β, MCP-1, and IFN-β in LPS-stimulated RAW264.7 macrophages. Kushenol C (50-100 μM;) significantly decreases the phosphorylation of both STAT1 molecules and STAT6 in a dose-dependent manner in LPS-stimulated RAW264.7 cells.Kushenol C upregulates the expression of HO-1 and its activities in the LPS-stimulated RAW264.7 macrophages. In HaCaT cells, Kushenol C prevents DNA damage and cell death by upregulating the endogenous antioxidant defense system involving glutathione, superoxide dismutase, and catalase, which prevents reactive oxygen species production from tert-butyl hydroperoxide (tBHP)-induced oxidative stress in HaCaT cells. Kushenol C inhibits BChE and AChE with IC50s of 54.86 and 33.13 μM.
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