产品
编 号：F544890
分子式：C10H14N5Na2O13P3
分子量：551.14
分子式：C10H14N5Na2O13P3
分子量：551.14
产品类型
规格
价格
是否有货
500mg
280
In-stock
1g
360
In-stock
5g
720
In-stock
结构图
CAS No: 987-65-5
产品详情
生物活性：
ATP disodium salt (Adenosine 5'-triphosphate disodium salt) is a central component of energy storage and metabolism in vivo, provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP disodium salt is an important endogenous signaling molecule in immunity and inflammation.
体内研究：
ATP disodium salt (50 mg/kg; i.p.) protects mice against bacterial infection in vivo.?ATP disodium salt induces the secretion of IL1β, KC and MIP-2 and neutrophils recruitment in vivo.Animal Model:Four-week-old Kunming mice (18-22 g)
Dosage:50 mg/kg
Administration:Intraperitoneal injection, before bacterial (E. coli) challenge
Result:Protected mice from bacterial infection.
体外研究：
ATP disodium salt (5mM; 1 hour) co-treatment with LPS (1 μg/ml) has a synergistic effect on the activation of the NLRP3 inflammasome in HGFs.?ATP disodium salt (2 mM; 0.5-24 hours) induces secretion of interleukin 1β, KC and MIP-2 from bone marrow derived macrophages (BMDMs) in vitro in a caspase-1 activation-dependent manner.?ATP disodium salt stimulats cytokine and chemokine secretion and inflammasome activation directly and indirectly induces in vitro neutrophil chemotaxis.
ATP disodium salt (Adenosine 5'-triphosphate disodium salt) is a central component of energy storage and metabolism in vivo, provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP disodium salt is an important endogenous signaling molecule in immunity and inflammation.
体内研究：
ATP disodium salt (50 mg/kg; i.p.) protects mice against bacterial infection in vivo.?ATP disodium salt induces the secretion of IL1β, KC and MIP-2 and neutrophils recruitment in vivo.Animal Model:Four-week-old Kunming mice (18-22 g)
Dosage:50 mg/kg
Administration:Intraperitoneal injection, before bacterial (E. coli) challenge
Result:Protected mice from bacterial infection.
体外研究：
ATP disodium salt (5mM; 1 hour) co-treatment with LPS (1 μg/ml) has a synergistic effect on the activation of the NLRP3 inflammasome in HGFs.?ATP disodium salt (2 mM; 0.5-24 hours) induces secretion of interleukin 1β, KC and MIP-2 from bone marrow derived macrophages (BMDMs) in vitro in a caspase-1 activation-dependent manner.?ATP disodium salt stimulats cytokine and chemokine secretion and inflammasome activation directly and indirectly induces in vitro neutrophil chemotaxis.
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