产品
编 号：F543537
分子式：C30H46NO7P
分子量：563.66
分子式：C30H46NO7P
分子量：563.66
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CAS No: 98048-97-6
产品详情
生物活性：
Fosinopril (SQ28555 free acid) is the ester proagent of angiotensin-converting enzyme (ACE) inhibitor with an IC50 value of 0.18 μM. Fosinopril demonstrates a non-competitive inhibition effect on ACE activity with an Ki value of 1.675 μM.
体内研究：
Fosinopril (4.67 mg/kg; p.o.; 4 weeks) downregulates the creatine kinase (CK) and lactate dehydrogenase (LDH) levels and againsts cardiac dysfunction and structural alteration in rat.Fosinopril (4.67 mg/kg; p.o.; 4 weeks) suppresses cleaved-caspase 3 expression and myocardial apoptosis in AMI rat model.Animal Model:HF post-acute myocardial infarction (AMI) rat model (SPF-grade Sprague-Dawley (SD) rats, 265 ± 15 g)
Dosage:4.67 mg/kg
Administration:Oral gavage; 4 weeks
Result:Inhibited cardiac dysfunction and structural alteration and suppressed apoptosis.
体外研究：
Fosinopril (0-100μM; 30 min) partially inhibits the cosedimentation of liposomes and recombinant LPLA2.Fosinopril (250 nM) shows no inhibition of the soluble esterase activity of LPLA2.Fosinopril (0.372, 0.744, 1.116 μM) displays a non-competitive inhibition effect on ACE activity with an Ki value of 1.675 μM.
Fosinopril (SQ28555 free acid) is the ester proagent of angiotensin-converting enzyme (ACE) inhibitor with an IC50 value of 0.18 μM. Fosinopril demonstrates a non-competitive inhibition effect on ACE activity with an Ki value of 1.675 μM.
体内研究：
Fosinopril (4.67 mg/kg; p.o.; 4 weeks) downregulates the creatine kinase (CK) and lactate dehydrogenase (LDH) levels and againsts cardiac dysfunction and structural alteration in rat.Fosinopril (4.67 mg/kg; p.o.; 4 weeks) suppresses cleaved-caspase 3 expression and myocardial apoptosis in AMI rat model.Animal Model:HF post-acute myocardial infarction (AMI) rat model (SPF-grade Sprague-Dawley (SD) rats, 265 ± 15 g)
Dosage:4.67 mg/kg
Administration:Oral gavage; 4 weeks
Result:Inhibited cardiac dysfunction and structural alteration and suppressed apoptosis.
体外研究：
Fosinopril (0-100μM; 30 min) partially inhibits the cosedimentation of liposomes and recombinant LPLA2.Fosinopril (250 nM) shows no inhibition of the soluble esterase activity of LPLA2.Fosinopril (0.372, 0.744, 1.116 μM) displays a non-competitive inhibition effect on ACE activity with an Ki value of 1.675 μM.
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