产品
编 号：F542615
分子式：C11H9N3O3S
分子量：263.27
分子式：C11H9N3O3S
分子量：263.27
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 97534-21-9
产品详情
生物活性：
Merbarone (NSC 336628) is an orally active inhibitor of topoisomerase II. Merbarone acts primarily by blocking topoisomerase II-mediated DNA cleavage without stabilizing topo II-DNA covalent complexes. Merbarone is an anticancer agent.
体内研究：
Merbarone (50 mg/kg; daily i.p. for 5 d) achieves a maximum increased life span (ILS) of 101% in P388 murine leukemia.Merbarone (124 mg/kg; daily p.o. for 9 d) has anti-tumor activity in mice.
体外研究：
Merbarone (1-100 μM) inhibits L1210 cells proliferation in a concentration-dependent manner, with an IC50 of 10 μM.Merbarone (10-200 μM; 10 min) inhibits DNA relaxation catalyzed by human topoisomerase IIα, with an IC50 of ～40 μM.Merbarone (25-200 μM; 6 min) blocks tyopoisomerase II-mediated DNA cleavage, with an IC50 of ～50 μM.Merbarone (100 μM; 6 min) inhibits topoisomerase II-mediated DNA cleavage in a global manner.Merbarone (100 μM; 6 min) does not impair topoisomerase II?DNA binding.Merbarone (200 μM; 4-16 min) does not inhibit topoisomerase II-catalyzed ATP hydrolysis.
Merbarone (NSC 336628) is an orally active inhibitor of topoisomerase II. Merbarone acts primarily by blocking topoisomerase II-mediated DNA cleavage without stabilizing topo II-DNA covalent complexes. Merbarone is an anticancer agent.
体内研究：
Merbarone (50 mg/kg; daily i.p. for 5 d) achieves a maximum increased life span (ILS) of 101% in P388 murine leukemia.Merbarone (124 mg/kg; daily p.o. for 9 d) has anti-tumor activity in mice.
体外研究：
Merbarone (1-100 μM) inhibits L1210 cells proliferation in a concentration-dependent manner, with an IC50 of 10 μM.Merbarone (10-200 μM; 10 min) inhibits DNA relaxation catalyzed by human topoisomerase IIα, with an IC50 of ～40 μM.Merbarone (25-200 μM; 6 min) blocks tyopoisomerase II-mediated DNA cleavage, with an IC50 of ～50 μM.Merbarone (100 μM; 6 min) inhibits topoisomerase II-mediated DNA cleavage in a global manner.Merbarone (100 μM; 6 min) does not impair topoisomerase II?DNA binding.Merbarone (200 μM; 4-16 min) does not inhibit topoisomerase II-catalyzed ATP hydrolysis.
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