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编 号：F542022
分子式：C21H27NO
分子量：309.45
分子式：C21H27NO
分子量：309.45
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CAS No: 972-02-1
产品详情
生物活性：
Diphenidol is a non-selective muscarinic M1-M4 receptor antagonist, has anti-arrhythmic activity. Diphenidol is also a potent non-specific blocker of voltage-gated ion channels (Na+, K+, and Ca2+) in neuronal cells. Diphenidol can be used in the study of antivertigo and antinausea.
体内研究：
Diphenidol (2, 10 μmoL/kg, 腹腔注射) 可降低慢性收缩损伤后大鼠的神经性异常痛和 TNF-α 过表达。Diphenidol (30 mg/kg, 静脉注射) 对运动和阿吗啡诱导的异食癖大鼠呕吐具有抑制作用。Animal Model:Chronic constriction injury (CCI) rat model
Dosage:2, 10 μmoL/kg
Administration:i.p., berore surgery, and on postoperative days 3, 6, 7, 11, 13 and 14.
Result:Increased mechanical withdrawal threshold in a dose-dependent manner and decreased the TNF-α level.
体外研究：
Diphenidol 可抑制钠电流并产生脊髓麻醉，在 -70 和 -100 mV 保持电位下，对小鼠神经母细胞瘤 N2A 细胞 IC50 分别为 0.77 和 62.6 μM。
Diphenidol is a non-selective muscarinic M1-M4 receptor antagonist, has anti-arrhythmic activity. Diphenidol is also a potent non-specific blocker of voltage-gated ion channels (Na+, K+, and Ca2+) in neuronal cells. Diphenidol can be used in the study of antivertigo and antinausea.
体内研究：
Diphenidol (2, 10 μmoL/kg, 腹腔注射) 可降低慢性收缩损伤后大鼠的神经性异常痛和 TNF-α 过表达。Diphenidol (30 mg/kg, 静脉注射) 对运动和阿吗啡诱导的异食癖大鼠呕吐具有抑制作用。Animal Model:Chronic constriction injury (CCI) rat model
Dosage:2, 10 μmoL/kg
Administration:i.p., berore surgery, and on postoperative days 3, 6, 7, 11, 13 and 14.
Result:Increased mechanical withdrawal threshold in a dose-dependent manner and decreased the TNF-α level.
体外研究：
Diphenidol 可抑制钠电流并产生脊髓麻醉，在 -70 和 -100 mV 保持电位下，对小鼠神经母细胞瘤 N2A 细胞 IC50 分别为 0.77 和 62.6 μM。
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