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编 号:F541669
分子式:C21H22ClN
分子量:323.86
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1g
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5g
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生物活性:
Cyproheptadine hydrochloride is a potent and orally active 5-HT2A receptor antagonist, with antidepressant and antiserotonergic effects. Cyproheptadine hydrochloride has antiplatelet and thromboprotective activities. Cyproheptadine hydrochloride can be used for the research of thromboembolic disorders.

体内研究:
Cyproheptadine hydrochloride (1 mg/kg;腹腔注射;每日一次,持续 5 天;C57BL/6 小鼠) 在体内发挥血栓保护作用。Animal Model:C57BL/6 mice (8-10 weeks old)
Dosage:1 mg/kg
Administration:Intraperitoneal injection, daily, for 5 days
Result:Prolonged occlusion times and tail bleeding times in mice.

体外研究:
Cyproheptadine hydrochloride (0.01-100 nM;1 minute) 在体外剂量依赖性地抑制血清素增强的 ADP 诱导的小鼠血小板聚集。Cyproheptadine hydrochloride (10 nM) 能够在体外抑制血小板中 15 μM 血清素增强 adp (1μM) 诱导的酪氨酸磷酸化Cyproheptadine hydrochloride 相关抗体:
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