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编 号：F541553
分子式：C16H16Cl3N
分子量：328.66
分子式：C16H16Cl3N
分子量：328.66
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CAS No: 96850-13-4
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生物活性：
Indatraline hydrochloride (Lu 19-005) is a non-selective monoamine transporter inhibitor that blocks the reuptake of neurotransmitters (dopamine, serotonin, and norepinephrine). Indatraline hydrochloride can be used for the research of antidepressive. Indatraline hydrochloride induces autophagy while simultaneously inhibiting cell proliferation. Indatraline hydrochloride may also serve to direct the development of new agents for autophagy-related diseases such as atherosclerosis or restenosis.
体内研究：
Indatraline (2 μM) hydrochloride 抑制平滑肌细胞的新生内膜积聚。
体外研究：
Indataline hydrochloride (0-5 μM;24小时;EGFP-LC3稳定细胞) 使LC3。Indataline hydrochloride (1-10 μM;24小时;HeLa细胞) 使EGFP-LC3荧光空泡在细胞质。Indataline hydrochloride (1-20 μM) 抑制平滑肌细胞增殖，IC50=15 μM。Indataline 还诱导细胞自噬，影响 AMPK/mTOR/S6K 信号轴。
Indatraline hydrochloride (Lu 19-005) is a non-selective monoamine transporter inhibitor that blocks the reuptake of neurotransmitters (dopamine, serotonin, and norepinephrine). Indatraline hydrochloride can be used for the research of antidepressive. Indatraline hydrochloride induces autophagy while simultaneously inhibiting cell proliferation. Indatraline hydrochloride may also serve to direct the development of new agents for autophagy-related diseases such as atherosclerosis or restenosis.
体内研究：
Indatraline (2 μM) hydrochloride 抑制平滑肌细胞的新生内膜积聚。
体外研究：
Indataline hydrochloride (0-5 μM;24小时;EGFP-LC3稳定细胞) 使LC3。Indataline hydrochloride (1-10 μM;24小时;HeLa细胞) 使EGFP-LC3荧光空泡在细胞质。Indataline hydrochloride (1-20 μM) 抑制平滑肌细胞增殖，IC50=15 μM。Indataline 还诱导细胞自噬，影响 AMPK/mTOR/S6K 信号轴。
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