产品
编 号：F541476
分子式：C28H32N8O6
分子量：576.6
分子式：C28H32N8O6
分子量：576.6
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
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10mg
询价
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25mg
询价
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50mg
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结构图
CAS No: 96760-69-9
产品详情
生物活性：
Adenosine amine congener (ADAC) is a selective A1 adenosine receptor agonist, can ameliorate noise- and Cisplatin-induced cochlear injury. Adenosine amine congener also has neuroprotective effects.
体内研究：
Adenosine amine congener (25-300?μg/kg/day; intraperitoneal injection; daily; for 5 days; male Wistar rats) treatment is most effective in the first 24 hours after noise exposure at doses >50?μg/kg, providing up to 21?dB protection. Adenosine amine congener mitigates noise-induced hearing loss in a dose- and time-dependent manner.Animal Model:Male Wistar rats (8-10 weeks old) treated with noise exposure
Dosage:25 μg/kg/day, 50 μg/kg/day, 100 μg/kg/day, 200 μg/kg/day, and 300?μg/kg/day
Administration:Intraperitoneal injection; daily; for 5 days
Result:Most effective in the first 24 hours after noise exposure at doses >50?μg/kg, and provided up to 21?dB protection (averaged across 8-28?kHz).
体外研究：
Adenosine amine congener can reduce oxidative stress in the noise-exposed cochlea, leading to protection of sensory hair cells. Adenosine amine congener also can reduce cisplatin-induced apoptosis in cochlear tissues, particularly in sensory hair cells and strial marginal cells. The mechanisms of otoprotection by Adenosine amine congener include inhibition of glutamate release via presynaptic A1 receptors and inhibition of voltage-gated Ca2+ channels, which can prevent activation of apoptotic and necrotic cell death pathways.
Adenosine amine congener (ADAC) is a selective A1 adenosine receptor agonist, can ameliorate noise- and Cisplatin-induced cochlear injury. Adenosine amine congener also has neuroprotective effects.
体内研究：
Adenosine amine congener (25-300?μg/kg/day; intraperitoneal injection; daily; for 5 days; male Wistar rats) treatment is most effective in the first 24 hours after noise exposure at doses >50?μg/kg, providing up to 21?dB protection. Adenosine amine congener mitigates noise-induced hearing loss in a dose- and time-dependent manner.Animal Model:Male Wistar rats (8-10 weeks old) treated with noise exposure
Dosage:25 μg/kg/day, 50 μg/kg/day, 100 μg/kg/day, 200 μg/kg/day, and 300?μg/kg/day
Administration:Intraperitoneal injection; daily; for 5 days
Result:Most effective in the first 24 hours after noise exposure at doses >50?μg/kg, and provided up to 21?dB protection (averaged across 8-28?kHz).
体外研究：
Adenosine amine congener can reduce oxidative stress in the noise-exposed cochlea, leading to protection of sensory hair cells. Adenosine amine congener also can reduce cisplatin-induced apoptosis in cochlear tissues, particularly in sensory hair cells and strial marginal cells. The mechanisms of otoprotection by Adenosine amine congener include inhibition of glutamate release via presynaptic A1 receptors and inhibition of voltage-gated Ca2+ channels, which can prevent activation of apoptotic and necrotic cell death pathways.
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