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编 号:F541468
分子式:C14H20Cl4I2N2
分子量:611.94
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5mg
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生物活性:
Chlorisondamine (diiodide) is a potent nicotinic acetylcholine receptor (nAChR) antagonist and a ganglion blocker. Chlorisondamine antagonizes some of nicotine's central actions in a potent, long-lasting and pharmacologically selective way.

体内研究:
Chlorisondamine (0.2, 1.0, 5.0 μg; IV; single dosage) antagonizes the depressant action of nicotine on vertical activity (0-20min) in a dose-dependent way at 1 and 2 weeks.Animal Model:Rats (treated once with nicotine 0.4 mg/kg, s.c.)
Dosage:0.2, 1.0, 5.0 μg
Administration:IV; single dosage
Result:Antagonized the depressant action of nicotine on vertical activity (0-20min) in a dose-dependent way at 1 and 2 weeks.
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