产品
编 号：F541464
分子式：C22H32N2O2
分子量：356.5
分子式：C22H32N2O2
分子量：356.5
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
结构图
CAS No: 96744-75-1
产品详情
生物活性：
U-69593 is a potent and selective κ1-opioid receptor agonist. U-69593 attenuates addictive agent-induced behavioral sensitization in the rat. U-69593 reduces anxiety and enhances spontaneous alternation memory in mice. U-69593 reduces calcium-dependent dialysate levels of dopamine and glutamate in the ventral striatum.
体内研究：
U-69593 (0.16 mg/kg；sc) 减轻成瘾剂诱导的大鼠行为敏化。U-69593 (1、10、25 nmol/μL；显微注射) 减少小鼠的焦虑并增强自发交替记忆。U-69593 (0.32 mg/kg；sc) 降低急性苯丙胺诱发的行为和钙依赖性透析液中多巴胺和腹侧纹状体中的谷氨酸。Animal Model:Rat
Dosage:0.16 mg/kg
Administration:S.c. (an acute injection of cocaine (20 mg/kg i.p.))
Result:Attenuated the acute and chronic effects of cocaine on locomotor activity and stereotypy.
Animal Model:CD-1 mice
Dosage:1, 10, 25 nmol/μL
Administration:Microinjection (in the infralimbic cortex (IL)), once every week, 2 weeks
Result:Dose-dependently prolonged transfer-latency (T-L) and produced a dose-dependent anxiolytic behavioural profile, and after 24 h, the mouse were observed small but detectable carry-over effects. In week 2, U-69593 dose-dependently prolonged T/L and produced an anxiolytic behavioural profile in the first EPM (elevated plus-maze) trial, but observed a robust anxiolytic behavioural profile.
Animal Model:280-350 g, male Wistar rats
Dosage:0.32 mg/kg
Administration:S.c. (followed 15 min later by an injection of amphetamine (2.5 mg/kg i.p.))
Result:Significantly reduced the amphetamine-stimulated increase in dialysate dopamine levels and blocked the ability of amphetamine to evoke an increase in dialysate glutamate levels.
U-69593 is a potent and selective κ1-opioid receptor agonist. U-69593 attenuates addictive agent-induced behavioral sensitization in the rat. U-69593 reduces anxiety and enhances spontaneous alternation memory in mice. U-69593 reduces calcium-dependent dialysate levels of dopamine and glutamate in the ventral striatum.
体内研究：
U-69593 (0.16 mg/kg；sc) 减轻成瘾剂诱导的大鼠行为敏化。U-69593 (1、10、25 nmol/μL；显微注射) 减少小鼠的焦虑并增强自发交替记忆。U-69593 (0.32 mg/kg；sc) 降低急性苯丙胺诱发的行为和钙依赖性透析液中多巴胺和腹侧纹状体中的谷氨酸。Animal Model:Rat
Dosage:0.16 mg/kg
Administration:S.c. (an acute injection of cocaine (20 mg/kg i.p.))
Result:Attenuated the acute and chronic effects of cocaine on locomotor activity and stereotypy.
Animal Model:CD-1 mice
Dosage:1, 10, 25 nmol/μL
Administration:Microinjection (in the infralimbic cortex (IL)), once every week, 2 weeks
Result:Dose-dependently prolonged transfer-latency (T-L) and produced a dose-dependent anxiolytic behavioural profile, and after 24 h, the mouse were observed small but detectable carry-over effects. In week 2, U-69593 dose-dependently prolonged T/L and produced an anxiolytic behavioural profile in the first EPM (elevated plus-maze) trial, but observed a robust anxiolytic behavioural profile.
Animal Model:280-350 g, male Wistar rats
Dosage:0.32 mg/kg
Administration:S.c. (followed 15 min later by an injection of amphetamine (2.5 mg/kg i.p.))
Result:Significantly reduced the amphetamine-stimulated increase in dialysate dopamine levels and blocked the ability of amphetamine to evoke an increase in dialysate glutamate levels.
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