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编 号：F541276
分子式：C17H22N8O2
分子量：370.41
分子式：C17H22N8O2
分子量：370.41
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CAS No: 96558-24-6
产品详情
生物活性：
RPH-2823, a basic triamterene derivative, induces a dose-dependent decrease in short-circuit current (SCC) and increase in transepithelial electrical resistance.
体内研究：
RPH 2823 (2.5 mumol/kg) can avoid the kaliuresis of 25 mumol/kg furosemide in male Wistar rats. RPH 2823 (1 mg/kg and 5 mg/kg, i.v.) has a terminal elimination half-life of 3 h. About 47% of the given dose are excreted unchanged with urine.
体外研究：
RPH-2823 influences transepithelial Na+ transport by interacting with the Na+ channel or a regulator site of it within the apical membrane.
RPH-2823, a basic triamterene derivative, induces a dose-dependent decrease in short-circuit current (SCC) and increase in transepithelial electrical resistance.
体内研究：
RPH 2823 (2.5 mumol/kg) can avoid the kaliuresis of 25 mumol/kg furosemide in male Wistar rats. RPH 2823 (1 mg/kg and 5 mg/kg, i.v.) has a terminal elimination half-life of 3 h. About 47% of the given dose are excreted unchanged with urine.
体外研究：
RPH-2823 influences transepithelial Na+ transport by interacting with the Na+ channel or a regulator site of it within the apical membrane.
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