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编 号：F541193
分子式：C24H29FN4O
分子量：408.51
分子式：C24H29FN4O
分子量：408.51
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CAS No: 96478-43-2
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生物活性：
Irindalone is a novel serotonin 5-HT2 antagonist.
体内研究：
Irindalone dose dependently lowers the blood pressure in spontaneously hypertensive rats (SHR) and renal hypertensive dogs.
体外研究：
Irindalone causes a concentration-related inhibition of serotonin-induced contractions and shifts the serotonin curve to the right. Irindalone is more potent in inhibiting the serotonin-induced contractions. Irindalone has a similar profile in vitro, with a high affinity for serotonin 5-HT2 receptors and about a 10 times lower affinity for α1-adrenoceptors.
Irindalone is a novel serotonin 5-HT2 antagonist.
体内研究：
Irindalone dose dependently lowers the blood pressure in spontaneously hypertensive rats (SHR) and renal hypertensive dogs.
体外研究：
Irindalone causes a concentration-related inhibition of serotonin-induced contractions and shifts the serotonin curve to the right. Irindalone is more potent in inhibiting the serotonin-induced contractions. Irindalone has a similar profile in vitro, with a high affinity for serotonin 5-HT2 receptors and about a 10 times lower affinity for α1-adrenoceptors.
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