产品
编 号：F540500
分子式：C15H18N4O
分子量：270.33
分子式：C15H18N4O
分子量：270.33
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CAS No: 959705-64-7
产品详情
生物活性：
TC-E 5005 is a potent and selective PDE10A inhibitor with IC50 values of 7.28, 239, 779, 919, 3,100, and 3,700?nM for PDE10A, 2A, 11A, 5A, 7B and 3A, respectively. TC-E 5005 inhibits adrenergic and neurogenic smooth muscle contractions in the human prostate.
体外研究：
TC-E 5005 (500?nM) inhibits norepinephrine or phenylephrine and EFS (electric field stimulation)-induced contraction of human prostate strips.TC-E 5005 (500?nM) shows amplification of treprostinil-induced relaxations, which were significant from 0.03 to 30?μM treprostinil.
TC-E 5005 is a potent and selective PDE10A inhibitor with IC50 values of 7.28, 239, 779, 919, 3,100, and 3,700?nM for PDE10A, 2A, 11A, 5A, 7B and 3A, respectively. TC-E 5005 inhibits adrenergic and neurogenic smooth muscle contractions in the human prostate.
体外研究：
TC-E 5005 (500?nM) inhibits norepinephrine or phenylephrine and EFS (electric field stimulation)-induced contraction of human prostate strips.TC-E 5005 (500?nM) shows amplification of treprostinil-induced relaxations, which were significant from 0.03 to 30?μM treprostinil.
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