产品
编 号:F539113
分子式:C16H12Cl2FN5
分子量:364.2
产品类型
结构图
CAS No: 957011-15-3
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产品详情
生物活性:
HBF-0259 is a potent and selective inhibitor of hepatitis B virus (HBV) surface antigen (HBsAg) secretion, with an EC50 of 1.5 μM in HepG2.2.15 cells. HBF-0259 has no effect on HBV DNA synthesis.
体外研究:
HBF-0259 (0.0158-50.0 μM) inhibits the HBsAg secretion (EC50=1.5 μM) in HepDE19 cells, with an CC50 of >50 μM.HBF-0259 (2-8 μM) significantly reduces the abundance of both L and M in the supernatants of HepG2.2.15 cells.