产品
编 号：F539032
分子式：C22H30ClFO5
分子量：428.92
分子式：C22H30ClFO5
分子量：428.92
产品类型
规格
价格
是否有货
结构图
CAS No: 956901-32-9
产品详情
生物活性：
Betamethasone hydrochloride is a synthetic glucocorticoid with anti-inflammatory and immunosuppressive activities. Betamethasone hydrochloride accelerates fetal lung maturation and induces gene expression and apoptosis.
体内研究：
Betamethasone (0.48 mg; i.v.gtt for 48 h) decreases the hypercapnia-induced increase in CBF due to decreased cerebral vasodilatation.Betamethasone (0.05 ml (1 mg/L); topical injection) ameliorates spinal nerve transection induced mechanical allodynia and thermal hyperalgesia, and reduces the activation of NF-κB and elevation of TNFα and IL-1β, and induces the expression of IL-10 in the rats brain.Animal Model:Rambouillet-Colombia ewes bred on a single occasion are received hypercapnic challenges
Dosage:0.48 mg
Administration:Injected into the fetal jugular vein at a rate of 1 ml/h (10 μg betamethasone/h) and maintained over the next 48 h.
Result:Decreased cerebral blood flow (CBF) in all brain regions measured except the hippocampus after 24 h of infusion.The reduction in CBF was diminished to about 25-30 % after 48 h of infusion.
体外研究：
Betamethasone (0.1-1 μM; 12 h) induces gene expression in L929 cells.Betamethasone (0.1-1 μM; 48 h) induces CEM C7 T-cells apoptosis.
Betamethasone hydrochloride is a synthetic glucocorticoid with anti-inflammatory and immunosuppressive activities. Betamethasone hydrochloride accelerates fetal lung maturation and induces gene expression and apoptosis.
体内研究：
Betamethasone (0.48 mg; i.v.gtt for 48 h) decreases the hypercapnia-induced increase in CBF due to decreased cerebral vasodilatation.Betamethasone (0.05 ml (1 mg/L); topical injection) ameliorates spinal nerve transection induced mechanical allodynia and thermal hyperalgesia, and reduces the activation of NF-κB and elevation of TNFα and IL-1β, and induces the expression of IL-10 in the rats brain.Animal Model:Rambouillet-Colombia ewes bred on a single occasion are received hypercapnic challenges
Dosage:0.48 mg
Administration:Injected into the fetal jugular vein at a rate of 1 ml/h (10 μg betamethasone/h) and maintained over the next 48 h.
Result:Decreased cerebral blood flow (CBF) in all brain regions measured except the hippocampus after 24 h of infusion.The reduction in CBF was diminished to about 25-30 % after 48 h of infusion.
体外研究：
Betamethasone (0.1-1 μM; 12 h) induces gene expression in L929 cells.Betamethasone (0.1-1 μM; 48 h) induces CEM C7 T-cells apoptosis.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备