产品
编 号：F538626
分子式：C24H35Cl2N3O4
分子量：500.46
分子式：C24H35Cl2N3O4
分子量：500.46
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
100mg
480
In-stock
200mg
768
In-stock
500mg
1280
In-stock
1g
询价
询价
5g
询价
询价
结构图
CAS No: 95635-56-6
产品详情
生物活性：
Ranolazine dihydrochloride (CVT 303 dihydrochloride) is an anti-angina agent that achieves its effects by inhibiting the late phase of inward sodium current (INa and IKr with IC50 values of 6 μM and 12 μM, respectively) without affecting heart rate or blood pressure (BP). Ranolazine dihydrochloride is also a partial fatty acid oxidation inhibitor.
体内研究：
Ranolazine (Bolus injection 10 mg/kg and infusion 9.6 mg/kg/h; bolus injection; for 145 minutes; male Wistar rats) treatment significantly reduces infarct size and cardiac troponin T release in rats subjected to left anterior descending coronary artery occlusion-reperfusion.Animal Model:Male Wistar rats (240-350 g)
Dosage:Bolus injection 10 mg/kg and infusion (9.6 mg/kg/h)
Administration:Bolus injection; for 145 minutes
Result:Significantly reduced infarct size and cardiac troponin T release in rats subjected to left anterior descending coronary artery occlusion-reperfusion.
Ranolazine dihydrochloride (CVT 303 dihydrochloride) is an anti-angina agent that achieves its effects by inhibiting the late phase of inward sodium current (INa and IKr with IC50 values of 6 μM and 12 μM, respectively) without affecting heart rate or blood pressure (BP). Ranolazine dihydrochloride is also a partial fatty acid oxidation inhibitor.
体内研究：
Ranolazine (Bolus injection 10 mg/kg and infusion 9.6 mg/kg/h; bolus injection; for 145 minutes; male Wistar rats) treatment significantly reduces infarct size and cardiac troponin T release in rats subjected to left anterior descending coronary artery occlusion-reperfusion.Animal Model:Male Wistar rats (240-350 g)
Dosage:Bolus injection 10 mg/kg and infusion (9.6 mg/kg/h)
Administration:Bolus injection; for 145 minutes
Result:Significantly reduced infarct size and cardiac troponin T release in rats subjected to left anterior descending coronary artery occlusion-reperfusion.
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