产品
编 号:F538422
分子式:C17H21N5
分子量:295.38
产品类型
结构图
CAS No: 956025-83-5
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产品详情
生物活性:
3MB-PP1, a bulky purine analog, is a Polo-like kinase 1 (Plk1) inhibitor. 3MB-PP1 blocks mitotic progression and cell division arise through target Plk1 in in cells expressing analog-sensitive Plk1 alleles. 3MB-PP1 specifically inhibits the activity of analog-sensitive Ssn3 (Cdk8). 3MB-PP1 inhibits Leu93 Mutant Zipper-interacting protein kinase (Leu93-ZIPK; IC50=2 μM). 3MB-PP1 can be used for the research of hypha formation of Candida albicans and cell division.
体外研究:
3MB-PP1 (5 μM; 3 hours) stimulates hyphal growth in a strain bearing analog-sensitive alleles of SSN3.