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编 号：F538143
分子式：(C4H6N2.C3H5ClO)x
分子式：(C4H6N2.C3H5ClO)x
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CAS No: 95522-45-5
产品详情
生物活性：
Colestilan (MCI-196) is a non-absorbed, non-calcium-based phosphate binder and is also a non-metallic, anion exchange resin. Colestilan is orally active and can be used for hypercholesterolaemia research.
体内研究：
Colestilan (MCI-196) (0.125 or 0.5 g content per 15 g of the feed; p.o.; 14 days) decreases blood phosphate and urinary phosphorus excretion in rats.Colestilan is able to improve hyperphosphataemia in rats with renal failure induced by adenine administration for 4 weeks.Animal Model:6-week old Wistar male rats
Dosage:0.125 or 0.5 g content per 15 g of the feed
Administration:Oral in feed, 14 days
Result:Dose dependently decreased blood phosphate and urinary phosphate excretion.
体外研究：
Colestilan (MCI-196) decreases cholesterol levels by bile acid adsorption through the gastrointestinal tract.Colestilan (1 g) binds 2.52?mmol of phosphate at 2–4?mM phosphate concentration and pH7.2 in vitro.
Colestilan (MCI-196) is a non-absorbed, non-calcium-based phosphate binder and is also a non-metallic, anion exchange resin. Colestilan is orally active and can be used for hypercholesterolaemia research.
体内研究：
Colestilan (MCI-196) (0.125 or 0.5 g content per 15 g of the feed; p.o.; 14 days) decreases blood phosphate and urinary phosphorus excretion in rats.Colestilan is able to improve hyperphosphataemia in rats with renal failure induced by adenine administration for 4 weeks.Animal Model:6-week old Wistar male rats
Dosage:0.125 or 0.5 g content per 15 g of the feed
Administration:Oral in feed, 14 days
Result:Dose dependently decreased blood phosphate and urinary phosphate excretion.
体外研究：
Colestilan (MCI-196) decreases cholesterol levels by bile acid adsorption through the gastrointestinal tract.Colestilan (1 g) binds 2.52?mmol of phosphate at 2–4?mM phosphate concentration and pH7.2 in vitro.
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