产品
编 号：F537477
分子式：C23H34NO5P
分子量：435.49
分子式：C23H34NO5P
分子量：435.49
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规格
价格
是否有货
10mM*1mL in DMSO
询价
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1mg
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5mg
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10mg
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结构图
CAS No: 95399-71-6
产品详情
生物活性：
Fosfenopril (Fosinoprilat) is a potent angiotensin converting enzyme (ACE) inhibitor. Fosfenopril alleviates lipopolysaccharide (LPS)-induced inflammation by inhibiting TLR4/NF-κB signaling in monocytes.
体内研究：
Fosfenopril (0.5 mg/kg bolus plus 0.1 mg/kg/min, IV, once) increases p-aminohippurate (PAH) clearance and glomerular filtration rate (GFR) in dogs.Animal Model:Famale mongrel dogs (n=7)
Dosage:0.5 mg/kg (1.1 mumol/kg) bolus plus 0.1 mg/kg/min (0.22 mumol/kg/min)
Administration:IV, once
Result:Increased p-aminohippurate (PAH) clearance and glomerular filtration rate (GFR) by 25 and 16%, respectively without changing arterial pressure (AP).
体外研究：
Fosfenopril (0-10 μM, 5 min) inhibits the expression of TLR4 which is elevated by LPS.Fosfenopril (0-10 μM, 1 h)attenuates the expression of NF-κB which is activated by LPS.Fosfenopril inhibits LPS-induced cytokines (IL-6, IL-1β, and TNF-α) expression.
Fosfenopril (Fosinoprilat) is a potent angiotensin converting enzyme (ACE) inhibitor. Fosfenopril alleviates lipopolysaccharide (LPS)-induced inflammation by inhibiting TLR4/NF-κB signaling in monocytes.
体内研究：
Fosfenopril (0.5 mg/kg bolus plus 0.1 mg/kg/min, IV, once) increases p-aminohippurate (PAH) clearance and glomerular filtration rate (GFR) in dogs.Animal Model:Famale mongrel dogs (n=7)
Dosage:0.5 mg/kg (1.1 mumol/kg) bolus plus 0.1 mg/kg/min (0.22 mumol/kg/min)
Administration:IV, once
Result:Increased p-aminohippurate (PAH) clearance and glomerular filtration rate (GFR) by 25 and 16%, respectively without changing arterial pressure (AP).
体外研究：
Fosfenopril (0-10 μM, 5 min) inhibits the expression of TLR4 which is elevated by LPS.Fosfenopril (0-10 μM, 1 h)attenuates the expression of NF-κB which is activated by LPS.Fosfenopril inhibits LPS-induced cytokines (IL-6, IL-1β, and TNF-α) expression.
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