产品
编 号：F536622
分子式：C22H19ClO3
分子量：366.84
分子式：C22H19ClO3
分子量：366.84
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
125
In-stock
5mg
250
In-stock
10mg
400
In-stock
50mg
1200
In-stock
结构图
CAS No: 95233-18-4
产品详情
生物活性：
Atovaquone (Atavaquone) is a potent, selective and orally active inhibitor of the parasite’s mitochondrial cytochrome?bc1?complex. Atovaquone is against human and ?P. falciparum?cytochrome?bc1?activity with IC50 values of 460 nM and 2.0 nM, respectively. Atovaquone is an antimalarial agent and has the potential for the investigation of neumocystis pneumonia, toxoplasmosis, malaria, and babesia.
体内研究：
Atovaquone (口服给药；100 mg/kg；每天一次) 对小鼠存活率有抑制作用，口服给药的小鼠在停用 Atovaquone 后22天内死亡，而对照组小鼠在第14天死亡。Animal Model:ICSBP?/??mice infected with 10 cysts of the ME49 strain of?T. gondii
Dosage:100 mg/kg
Administration:Oral administration
Result:Improved mice survival rate to 22 days compared to vehicle.
体外研究：
Atovaquone 靶向线粒体电子传递链疟原虫细胞色素 bc1 复合体的 Qo 位点。Atovaquone 有效抵抗蚊子从配子生产、受精、受精卵形成到成熟 ookinete 的发育，并证明 IC50 为 67 nM，进一步证明了传播阻断潜力。
Atovaquone (Atavaquone) is a potent, selective and orally active inhibitor of the parasite’s mitochondrial cytochrome?bc1?complex. Atovaquone is against human and ?P. falciparum?cytochrome?bc1?activity with IC50 values of 460 nM and 2.0 nM, respectively. Atovaquone is an antimalarial agent and has the potential for the investigation of neumocystis pneumonia, toxoplasmosis, malaria, and babesia.
体内研究：
Atovaquone (口服给药；100 mg/kg；每天一次) 对小鼠存活率有抑制作用，口服给药的小鼠在停用 Atovaquone 后22天内死亡，而对照组小鼠在第14天死亡。Animal Model:ICSBP?/??mice infected with 10 cysts of the ME49 strain of?T. gondii
Dosage:100 mg/kg
Administration:Oral administration
Result:Improved mice survival rate to 22 days compared to vehicle.
体外研究：
Atovaquone 靶向线粒体电子传递链疟原虫细胞色素 bc1 复合体的 Qo 位点。Atovaquone 有效抵抗蚊子从配子生产、受精、受精卵形成到成熟 ookinete 的发育，并证明 IC50 为 67 nM，进一步证明了传播阻断潜力。
产品资料
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