产品
编 号：F535989
分子式：C23H19N3O
分子量：353.42
分子式：C23H19N3O
分子量：353.42
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
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10mg
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50mg
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100mg
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结构图
CAS No: 951650-22-9
产品详情
生物活性：
NS11394 is an orally active and unique subtype-selective GABAA positive allosteric receptor (PAM), with a Ki of ~0.5 nM. NS11394 shows a selectivity profile in the order of GABAA-5 > α3 > α2 > α1-containing receptors. NS11394 has anxiolytic and anti-inflammatory properties.
体内研究：
NS11394 (1-120 mg/kg) selectively attenuates injury-induced nociceptive behaviors in the formalin test.NS11394 (1–10 mg/kg) markedly attenuates the deficit in hindpaw weight bearing [F(4,61) = 7.569, p < 0.001] in CFA rats.Animal Model:Adult male Sprague-Dawley rats.
Dosage:1-120 mg/kg.
Administration:Orally.
Result:Significantly attenuated motor function compared with corresponding vehicle responses.Significantly reduced flinching behavior during interphase [F(3,30) = 4.139, p < 0.05] and the second phase [F(3,30) =11.033, p < 0.001] of the formalin test compared with vehicle treatment indicative of a selective effect on injury-induced nociceptive transmission.
NS11394 is an orally active and unique subtype-selective GABAA positive allosteric receptor (PAM), with a Ki of ~0.5 nM. NS11394 shows a selectivity profile in the order of GABAA-5 > α3 > α2 > α1-containing receptors. NS11394 has anxiolytic and anti-inflammatory properties.
体内研究：
NS11394 (1-120 mg/kg) selectively attenuates injury-induced nociceptive behaviors in the formalin test.NS11394 (1–10 mg/kg) markedly attenuates the deficit in hindpaw weight bearing [F(4,61) = 7.569, p < 0.001] in CFA rats.Animal Model:Adult male Sprague-Dawley rats.
Dosage:1-120 mg/kg.
Administration:Orally.
Result:Significantly attenuated motor function compared with corresponding vehicle responses.Significantly reduced flinching behavior during interphase [F(3,30) = 4.139, p < 0.05] and the second phase [F(3,30) =11.033, p < 0.001] of the formalin test compared with vehicle treatment indicative of a selective effect on injury-induced nociceptive transmission.
产品资料
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